Novel linear polyene antibiotics: Linearmycins

Two novel linear polyene antibiotics, termed linearmycin A1 and B2, have been isolated from the mycelial extracts of Streptomyces sp.no.30 and characterized as compounds 1 and 2, respectively, These compounds have similar, long linear structures terminating with amino and carboxylic acid groups, and show antifungal and antibacterial activity, The incorporation experiments using C-13-labelled acetate and propionate suggest that 1 is biosynthesized from one gamma-aminobutyric acid, 24 acetate and 4 propionate molecules, by a polyketide pathway.