Design and synthesis of photoactivatable coumarin-containing HIV-1 integrase inhibitors

被引：0
|
作者：
Zhao, H [1 ]
Neamati, N [1 ]
Pommier, Y [1 ]
Burke, TR [1 ]
机构：
[1] NCI,MOL PHARMACOL LAB,DIV BASIC SCI,NIH,BETHESDA,MD 20892
来源：
HETEROCYCLES | 1997年 / 45卷 / 11期
关键词：
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Three dimeric coumarin analogues (1-3) were prepared, each containing the photoactivatable benzophenone moiety. These compounds exhibited low micromolar IC50 values against HIV-1 integrase mediated 3'-processing and strand transfer, and may represent useful probes for elucidating enzyme-inhibitor interactions.
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页码：2277 / 2282
页数：6
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