Prostaglandin E2 activates Epac1/Rap1 signaling pathway via elevation of cAMP in synovial fibroblasts from patients with rheumatoid arthritis.

被引:0
|
作者
Kojima, Fumiaki [1 ]
Kapoor, Mohit [1 ]
Yang, Lihua [1 ]
Crofford, Leslie J. [1 ]
机构
[1] Univ Kentucky, Lexington, KY USA
来源
ARTHRITIS AND RHEUMATISM | 2006年 / 54卷 / 09期
关键词
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:S301 / S301
页数:1
相关论文
共 50 条
  • [41] Thrombin induces chemokine RANTES production via protease-activated receptor-1 in synovial cells from patients with rheumatoid arthritis.
    Hirano, F
    Kobayashi, A
    Maruyama, N
    Hirano, Y
    Fukawa, E
    Makino, I
    JOURNAL OF RHEUMATOLOGY, 2001, 28 : 81 - 81
  • [42] Candida albicans induces cyclo-oxygenase 2 expression and prostaglandin E2 production in synovial fibroblasts through an extracellular-regulated kinase 1/2 dependent pathway
    Lee, Herng-Sheng
    Lee, Chung-Shinn
    Yang, Chi-Jung
    Su, Sui-Long
    Salter, Donald M.
    ARTHRITIS RESEARCH & THERAPY, 2009, 11 (02)
  • [43] Prostaglandin E2 promotes pathological retinal neovascularisation via EP4R-EGFR-Gab1-AKT signaling pathway
    Xie, Tianhua
    Zhang, Zhonghong
    Cui, Yuqing
    Shu, Yishun
    Liu, Yanqiu
    Zou, Jian
    Wang, Man
    Wang, Yangningzhi
    Yang, Qian
    Pan, Xubin
    Cai, Jiping
    Sun, Xiaodong
    Yao, Yong
    Wang, Xiaolu
    EXPERIMENTAL EYE RESEARCH, 2021, 205
  • [44] In vivo gene expression of type 1 and type 2 cytokines in synovial tissues from patients in early stages of rheumatoid, reactive and undifferentiated arthritis.
    Kotake, S
    Schumacher, HR
    Yarboro, CH
    Arayssi, TK
    Pando, JA
    Kanik, KS
    Gourley, MF
    Klippel, JH
    Wilder, RL
    ARTHRITIS AND RHEUMATISM, 1996, 39 (09): : 545 - 545
  • [45] Prostaglandin E2 activates the mTORC1 pathway through an EP4/cAMP/PKA and EP1/calcium-mediated mechanisms in human pancreatic carcinoma cells
    Chang, Hui-Hua
    Young, Steven
    Sinnett-Smith, James
    Chou, Caroline Ei Ne
    Hines, Oscar Joe
    Rozengurt, Enrique
    Eibl, Guido
    CANCER RESEARCH, 2015, 75
  • [46] Downregulation of protease-activated receptor-1 in human lung fibroblasts is specifically mediated by the prostaglandin E2 receptor EP2 through cAMP elevation and protein kinase A
    Sokolova, Elena
    Hartig, Roland
    Reiser, Georg
    FEBS JOURNAL, 2008, 275 (14) : 3669 - 3679
  • [47] Novel anti-inflammatory target of geniposide: Inhibiting Itgβ1/Ras-Erk1/2 signal pathway via the miRNA-124a in rheumatoid arthritis synovial fibroblasts
    Wang, Yan
    Dai, Li
    Wu, Hong
    Zhang, Zheng-rong
    Wang, Wen-yu
    Fu, Jun
    Deng, Ran
    Li, Feng
    Dai, Xue-jing
    Zhan, Xiang
    INTERNATIONAL IMMUNOPHARMACOLOGY, 2018, 65 : 284 - 294
  • [48] Prostaglandin E2 activates the mTORC1 pathway through an EP4/cAMP/PKA- and EP1/Ca2+-mediated mechanism in the human pancreatic carcinoma cell line PANC-1
    Chang, Hui-Hua
    Young, Steven H.
    Sinnett-Smith, James
    Chou, Caroline Ei Ne
    Moro, Aune
    Hertzer, Kathleen M.
    Hines, Oscar Joe
    Rozengurt, Enrique
    Eibl, Guido
    AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2015, 309 (10): : C639 - C649
  • [49] Hyaluronic acid inhibits mRNA expression of proinflammatory cytokines and cyclooxygenase-2/prostaglandin E2 production via CD44 in interleukin-1-stimulated subacromial synovial fibroblasts from patients with rotator cuff disease
    Mitsui, Yasuhiro
    Gotoh, Masafumi
    Nakama, Kenjirou
    Yamada, Tetsu
    Higuchi, Fujio
    Nagata, Kensei
    JOURNAL OF ORTHOPAEDIC RESEARCH, 2008, 26 (07) : 1032 - 1037
  • [50] Cyclic compressive loading on 3D tissue of human synovial fibroblasts upregulates prostaglandin E2 via COX-2 production without IL-1β and TNF-α
    Shimomura, K.
    Kanamoto, T.
    Kita, K.
    Akamine, Y.
    Nakamura, N.
    Mae, T.
    Yoshikawa, H.
    Nakata, K.
    BONE & JOINT RESEARCH, 2014, 3 (09): : 280 - 288