Integration of denosumab therapy in the management of giant cell tumors of bone

被引：7
|
作者：
Miles, Daniel T. [1 ]
Voskuil, Ryan T. [2 ,3 ]
Dale, Wood [4 ]
Mayerson, Joel L. [2 ,3 ]
Scharschmidt, Thomas J. [2 ,3 ]
机构：
[1] Univ Tennessee, Coll Med, Dept Orthopaed Surg, Chattanooga, TN USA
[2] Ohio State Univ, James Canc Hosp, Div Musculoskeletal Oncol, Wexner Med Ctr,Nationwide Childrens Hosp, Columbus, OH 43210 USA
[3] Ohio State Univ, Solove Res Inst, Wexner Med Ctr, Nationwide Childrens Hosp, Columbus, OH 43210 USA
[4] Univ Mississippi, Sch Med, Dept Orthopaed & Rehabil, University, MS 38677 USA
来源：
JOURNAL OF ORTHOPAEDICS | 2020年 / 22卷
关键词：
Denosumab; RANKL; Giant cell tumor of the bone (GCTB); PHASE-II TRIAL; LOCAL RECURRENCE; ZOLEDRONIC ACID; BREAST-CANCER; OPEN-LABEL; PROSTATE-CANCER; GENE-EXPRESSION; CATHEPSIN-K; RANK LIGAND; OSTEOPROTEGERIN;
D O I：
10.1016/j.jor.2020.03.020
中图分类号：
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];
学科分类号：
摘要：
A review of the literature indicated denosumab is gaining favorability in the oncology community, particularly with increasing frequency in GCTB. Will denosumab be the breakthrough GCTB treatment? Here, we provide a pertinent case example, a review of the literature regarding the history and basic science behind the use of denosumab for GCTB, highlight the newest insights into the dosing and duration of treatment, and note advancements in the field.
引用
收藏
页码：38 / 47
页数：10
相关论文
共 50 条
  • [31] Blue lacy matrix in giant cell tumour of bone with or without denosumab therapy
    Toda, Yu
    Ishihara, Shin
    Kawai, Akira
    Yoshida, Akihiko
    VIRCHOWS ARCHIV, 2023, 483 (01) : 125 - 129
  • [32] Denosumab and giant cell tumour of bone-a review and future management considerations
    Xu, S. F.
    Adams, B.
    Yu, X. C.
    Xu, M.
    CURRENT ONCOLOGY, 2013, 20 (05) : E442 - E447
  • [33] Establishment of a Collective for histomorphological Risk Stratification of Giant Cell Tumors with and without Denosumab Therapy
    Arndt, S.
    Hartmann, W.
    Rokusz, A.
    Leinauer, B.
    von Baer, A.
    Schultheiss, M.
    Pablik, J.
    Fritzsche, H.
    Mogler, C.
    Baumhoer, D.
    Mellert, K.
    Moeller, P.
    Sendroi, M.
    Jundt, G.
    Barth, T. F.
    OSTEOLOGIE, 2023, 32 (01) : 73 - 75
  • [34] Denosumab Treatment for Giant Cell Tumors, Aneurysmal Bone Cysts, and Fibrous Dysplasia—Risks and Benefits
    Kristen S. Pan
    Alison M. Boyce
    Current Osteoporosis Reports, 2021, 19 : 141 - 150
  • [35] Denosumab-Treated Giant Cell Tumor of Bone May Mimic Primary Benign and Malignant Tumors of Bone
    Wojcik, J. B.
    Chebib, I. A.
    Rosenberg, A. E.
    Nielsen, G. P.
    Desphande, V.
    LABORATORY INVESTIGATION, 2014, 94 : 32A - 32A
  • [36] Do Unresectable Giant Cell Tumors of Bone Treated With Denosumab Progress After Discontinuation of Treatment?
    de la Calva, Carolina
    DENO Res Grp, Manuel
    Angulo, Manuel
    Gonzalez-Rojo, Paula
    Peiro, Ana
    Machado, Pau
    Cebrian, Juan Luis
    Garcia-Maroto, Roberto
    Valcarcel, Antonio
    Puertas, Pablo
    Valero-Cifuentes, Gregorio
    Pablos, Oscar
    Maireles, Miriam
    Fontalva, Maria Luisa
    Chaves, Ivan
    Orce, Aida
    Coll-Mesa, Luis
    Perez, Israel
    Gonzalez, Fausto
    del Carmen Sanz, Maria
    Gracia, Isidro
    CANCER REPORTS, 2025, 8 (01)
  • [37] Protein Expression Profiles Corresponding to Histological Changes with Denosumab Treatment in Giant Cell Tumors of Bone
    Suehara, Yoshiyuki
    Okubo, Taketo
    Kurihara, Taisei
    Hayashi, Takuo
    Kohsaka, Shinji
    Kazuno, Saiko
    Sono, Kei
    Hasegawa, Nobuhiko
    Miura, Yoshiki
    Akaike, Keisuke
    Kim, Youngji
    Takamochi, Kazuya
    Takahashi, Fumiyuki
    Ueno, Takashi
    Kaneko, Kazuo
    Saito, Tsuyoshi
    PROTEOMICS CLINICAL APPLICATIONS, 2019, 13 (05)
  • [38] Denosumab-Treated Giant Cell Tumor of Bone May Mimic Primary Benign and Malignant Tumors of Bone
    Wojcik, J. B.
    Chebib, I. A.
    Rosenberg, A. E.
    Nielsen, G. P.
    Desphande, V.
    MODERN PATHOLOGY, 2014, 27 : 32A - 32A
  • [39] Comparison of Denosumab and Zoledronic acid as neoadjuvant therapy in patients with giant cell tumor of bone
    Kanwat, Himanshu
    Banjara, Roshan
    Kumar, Venkatesan Sampath
    Majeed, Abdul
    Gamnagatti, Shivanand
    Khan, Shah Alam
    JOURNAL OF ORTHOPAEDIC SURGERY, 2021, 29 (02)
  • [40] Critical Hypercalcemia Following Discontinuation of Denosumab Therapy for Metastatic Giant Cell Tumor of Bone
    Gossai, Nathan
    Hilgers, Megan V.
    Polgreen, Lynda E.
    Greengard, Emily G.
    PEDIATRIC BLOOD & CANCER, 2015, 62 (06) : 1078 - 1080
12345