Modeling of HIV-1 Infection Incorporating Cell-to-Cell Transmission and Viral Clearance of CD4+T cells

被引：0
|
作者：
Sutimin [1 ]
Sunarsih [1 ]
Tjahjana, R. Heru [1 ]
机构：
[1] Diponegoro Univ, Dept Math, Jl Prof H Soedarto SH, Tembalang 50275, Semarang, Indonesia
来源：
SYMPOSIUM ON BIOMATHEMATICS 2019 (SYMOMATH 2019) | 2020年 / 2264卷
关键词：
THERAPY;
D O I：
10.1063/5.0024193
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
CD4(+) T cells are as immune system destroyed by HIV (Human Immunodeficiency Virus) and play pivotal role in the spread of viral transmission. The viral transmission in host cells occurred through cell-cell contact and cell-free virus. We develop a mathematical model by incorporating the viral infection through cell-cell, viral degradation, and the effect of antiretroviral treatments. The basic reproduction ratio is predicted by alternative reproduction ratio to investigate the uninfected and infected equilibrium points for the model. Simulation results are conducted to explore the implication of the combination of RTI and PI therapy in various scenarios and the effect of viral clearance. When the host cells is still enough able in responding HIV-1, the viral count can be eliminated up to undetected virus in the body.
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