E Proteins and ID Proteins: Helix-Loop-Helix Partners in Development and Disease

被引：114
|
作者：
Wang, Lan-Hsin [1 ]
Baker, Nicholas E. [1 ,2 ,3 ]
机构：
[1] Albert Einstein Coll Med, Dept Genet, Bronx, NY 10461 USA
[2] Albert Einstein Coll Med, Dept Dev & Mol Biol, Bronx, NY 10461 USA
[3] Albert Einstein Coll Med, Dept Ophthalmol & Visual Sci, Bronx, NY 10461 USA
来源：
DEVELOPMENTAL CELL | 2015年 / 35卷 / 03期
关键词：
PITT-HOPKINS-SYNDROME; DIAMOND-BLACKFAN ANEMIA; PROTEASOME-MEDIATED DEGRADATION; ENDOTHELIAL CORNEAL-DYSTROPHY; LYMPHOBLASTOID CELL-LINES; TRANSCRIPTION FACTOR 4; TGF-BETA RECEPTOR; HIGH-GRADE GLIOMA; LYMPHOCYTE DEVELOPMENT; NEGATIVE REGULATOR;
D O I：
10.1016/j.devcel.2015.10.019
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The basic Helix-Loop-Helix (bHLH) proteins represent a well-known class of transcriptional regulators. Many bHLH proteins act as heterodimers with members of a class of ubiquitous partners, the E proteins. A widely expressed class of inhibitory heterodimer partners-the Inhibitor of DNA-binding (ID) proteins-also exists. Genetic and molecular analyses in humans and in knockout mice implicate E proteins and ID proteins in a wide variety of diseases, belying the notion that they are non-specific partner proteins. Here, we explore relationships of E proteins and ID proteins to a variety of disease processes and highlight gaps in knowledge of disease mechanisms.
引用
收藏
页码：269 / 280
页数：12
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