KMnO4-mediated oxidative C-N bond cleavage of tertiary amines: Synthesis of amides and sulfonamides

被引：12
|
作者：
Zhang, Zhang [1 ]
Liu, Yong-Hong [1 ]
Zhang, Xi [1 ]
Wang, Xi-Cun [1 ]
机构：
[1] Northwest Normal Univ, Coll Chem & Chem Engn, Gansu Int Sci & Technol Cooperat Base Water Reten, Lanzhou 730070, Gansu, Peoples R China
来源：
TETRAHEDRON | 2019年 / 75卷 / 19期
基金：
中国国家自然科学基金;
关键词：
Tertiary amine; C-N cleavage; KMnO4; Acyl chloride; Amide; CARBON-NITROGEN BOND; COOPERATIVE CATALYSIS; METAL-FREE; H BONDS; ACTIVATION; AMIDATION; AMINATION; ARYLATION; DERIVATIVES; ALKYLATION;
D O I：
10.1016/j.tet.2019.03.047
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
KMnO4-mediated oxidative C-N bond cleavage of tertiary amines producing secondary amine was introduced, which was trapped by electrophiles (acyl chloride and sulfonyl chloride) to form amides and sulfonamides. The reaction could take place at mild condition, tolerating a wide range of function groups and affording products in moderate to excellent yields. (C) 2019 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2763 / 2770
页数：8
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