STATISTICAL ANALYSIS TO COMPARE VARIOUS IN VITRO CRITERIA FOR PREDICTING ORGANIC ANION TRANSPORTING POLYPEPTIDES 1B1 (OATP1B1)-MEDIATED DRUG INTERACTIONS IN VIVO

被引：0
|
作者：
Arya, V. [1 ]
Vaidyanathan, J. [1 ]
Yoshida, K. [2 ]
Yang, X. [1 ]
Zhang, L. [1 ]
机构：
[1] US FDA, Off Clin Pharmacol, Off Translat Sci, Ctr Drug Evaluat & Res, Silver Spring, MD USA
[2] US FDA, Silver Spring, MD USA
来源：
CLINICAL PHARMACOLOGY & THERAPEUTICS | 2017年 / 101卷 / S1期
关键词：
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
PI-008
引用
收藏
页码：S21 / S22
页数：2
相关论文
共 50 条
  • [21] Potential Risk of Food-Drug Interactions: Citrus Polymethoxyflavones and Flavanones as Inhibitors of the Organic Anion Transporting Polypeptides (OATP) 1B1, 1B3, and 2B1
    Gzona Bajraktari-Sylejmani
    Johanna Weiss
    European Journal of Drug Metabolism and Pharmacokinetics, 2020, 45 : 809 - 815
  • [22] Analysis of amino acid residues in the predicted transmembrane pore influencing transport kinetics of the hepatic drug transporter organic anion transporting polypeptide 1B1 (OATP1B1)
    Gruetz, Moritz
    Sticht, Heinrich
    Glaeser, Hartmut
    Fromm, Martin F.
    Koenig, Jorg
    BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2016, 1858 (11): : 2894 - 2902
  • [23] Potential role of organic anion transporting polypeptide 1B1 (OATP1B1) in the selective hepatic uptake of hematoporphyrin monomethyl ether isomers
    Li, Xiu-li
    Guo, Zi-tao
    Wang, Ye-dong
    Chen, Xiao-yan
    Liu, Jia
    Zhong, Da-fang
    ACTA PHARMACOLOGICA SINICA, 2015, 36 (02) : 268 - 280
  • [24] Potential role of organic anion transporting polypeptide 1B1 (OATP1B1) in the selective hepatic uptake of hematoporphyrin monomethyl ether isomers
    Xiu-li Li
    Zi-tao Guo
    Ye-dong Wang
    Xiao-yan Chen
    Jia Liu
    Da-fang Zhong
    Acta Pharmacologica Sinica, 2015, 36 : 268 - 280
  • [25] Investigation of fluorescein derivatives as substrates of organic anion transporting polypeptide (OATP) 1B1 to develop sensitive fluorescence-based OATP1B1 inhibition assays
    Izumi, Saki
    Nozaki, Yoshitane
    Komori, Takafumi
    Takenaka, Osamu
    Maeda, Kazuya
    Kusuhara, Hiroyuki
    Sugiyama, Yuichi
    DRUG METABOLISM REVIEWS, 2016, 48 : 149 - 150
  • [26] Investigation of Fluorescein Derivatives as Substrates of Organic Anion Transporting Polypeptide (OATP) 1B1 To Develop Sensitive Fluorescence-Based OATP1B1 Inhibition Assays
    Izumi, Saki
    Nozaki, Yoshitane
    Komori, Takafumi
    Takenaka, Osamu
    Maeda, Kazuya
    Kusuhara, Hiroyuki
    Sugiyama, Yuichi
    MOLECULAR PHARMACEUTICS, 2016, 13 (02) : 438 - 448
  • [27] Contribution of organic anion transporting polypeptide (OATP) 1B1 and OATP1B3 to hepatic uptake of nateglinide, and the prediction of drug-drug interactions via these transporters
    Takanohashi, Toshiyuki
    Kubo, Satoru
    Arisaka, Harumi
    Shinkai, Kenji
    Ubukata, Kazuyuki
    JOURNAL OF PHARMACY AND PHARMACOLOGY, 2012, 64 (02) : 199 - 206
  • [28] Effect of Steroids on Transport Characteristics of the Organic Anion Transporting Polypeptides (OATP) 1A2, 1B1, 1B3 and 2B1
    Koenen, Anna B.
    Koeck, Kathleen
    Keiser, Markus
    Siegmund, Werner
    Grube, Markus
    Kroemer, Heyo K.
    DRUG METABOLISM REVIEWS, 2010, 42 : 316 - 317
  • [29] The Role of Adopted Orphan Nuclear Receptors in the Regulation of an Organic Anion Transporting Polypeptide 1B1 (OATP1B1) under the Action of Sex Hormones
    Shchulkin, Aleksey V.
    Abalenikhina, Yulia V.
    Slepnev, Aleksandr A.
    Rokunov, Egor D.
    Yakusheva, Elena N.
    CURRENT ISSUES IN MOLECULAR BIOLOGY, 2023, 45 (12) : 9593 - 9605
  • [30] WHAT CRITERIA MAY BE APPROPRIATE IN DETERMINING THE NEED FOR IN VIVO EVALUATION OF A NEW MOLECULAR ENTITY'S (NME'S) POTENTIAL TO INHIBIT OATP1B1 (ORGANIC ANION TRANSPORTING POLYPEPTIDE 1B1).
    Vaidyanathan, J.
    Arya, V.
    Agarwal, S.
    Vieira, M. de L. T.
    Zhao, P.
    Huang, S.
    Zhang, L.
    CLINICAL PHARMACOLOGY & THERAPEUTICS, 2012, 91 : S53 - S53
12345