Lipoic Acid Metabolism as a Potential Chemotherapeutic Target Against Plasmodium falciparum and Staphylococcus aureus

被引：2
|
作者：
Rei Yan, Sun Liu [1 ]
Wakasuqui, Felipe [1 ]
Du, Xiaochen [2 ]
Groves, Matthew R. [2 ]
Wrenger, Carsten [1 ]
机构：
[1] Univ Sao Paulo, Inst Biomed Sci ICB, Dept Parasitol, Unit Drug Discovery, Sao Paulo, Brazil
[2] Univ Groningen, Groningen Res Inst Pharm, Dept Drug Design, Struct Biol Drug Design, Groningen, Netherlands
来源：
FRONTIERS IN CHEMISTRY | 2021年 / 9卷
基金：
巴西圣保罗研究基金会;
关键词：
Lipoic acid; malaria; protein lipoylation; Plasmodium; S; aureus; Lipoic acid (LA); lipoylation;
D O I：
10.3389/fchem.2021.742175
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Lipoic acid (LA) is an organic compound that plays a key role in cellular metabolism. It participates in a posttranslational modification (PTM) named lipoylation, an event that is highly conserved and that occurs in multimeric metabolic enzymes of very distinct microorganisms such as Plasmodium sp. and Staphylococcus aureus, including pyruvate dehydrogenase (PDH) and alpha-ketoglutarate dehydrogenase (KDH). In this mini review, we revisit the recent literature regarding LA metabolism in Plasmodium sp. and Staphylococcus aureus, by covering the lipoate ligase proteins in both microorganisms, the role of lipoate ligase proteins and insights for possible inhibitors of lipoate ligases.
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页数：7
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