Antithrombotic activity of avian crown dermatan sulfate

被引：16
|
作者：
Kyogashima, M
Onaya, J
Miyauchi, S
Arai, M
Shibata, Y
Suda, A
Sakai, T
Takada, Y
Takada, A
机构：
[1] Seikagaku Corp, Tokyo Res Inst, Tokyo 2070021, Japan
[2] Hamamatsu Univ Sch Med, Dept Physiol, Hammatsu, Japan
来源：
THROMBOSIS RESEARCH | 1999年 / 96卷 / 06期
关键词：
avian crown dermatan sulfate; anticoagulant; fibrinolysis; thrombosis;
D O I：
10.1016/S0049-3848(99)00138-3
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The antithrombotic activity of dermatan sulfate from avian crown with the mean molecular weight of 38000 was compared to those from bovine intestine with the mean molecular weight of 16000 in vivo and in vitro. In an in vitro test. bovine intestine dermatan sulfate exhibited stronger effects on stimulation of heparin cofactor II and activation of Glu-plasminogen by tissue plasminogen activator. In vivo, avian crown dermatan sulfate more effectively prevented the development of thrombus in a rat deep vein thrombosis model, The measurement of plasma levels of these two kinds of dermatan sulfate revealed that avian crown dermatan sulfate circulated in higher concentration and longer duration than bovine intestine dermatan sulfate after intravenous administration to rats. (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
下载
收藏
页码：459 / 465
页数：7
相关论文
共 50 条
  • [21] The relationship between the structure of dermatan sulfate derivatives and their antithrombotic activities
    Du, Hai-Yan
    Ji, Sheng-Li
    Song, Hai-Feng
    Ye, Qi-Nong
    Cao, Ji-Chao
    THROMBOSIS RESEARCH, 2007, 119 (03) : 377 - 384
  • [22] POTENTIATION OF THE ANTITHROMBOTIC ACTION OF DERMATAN SULFATE BY SMALL AMOUNTS OF HEPARIN
    THOMAS, DP
    GRAY, E
    MERTON, RE
    THROMBOSIS AND HAEMOSTASIS, 1990, 64 (02) : 290 - 293
  • [23] LOW-MOLECULAR-WEIGHT DERMATAN SULFATE AS AN ANTITHROMBOTIC AGENT - STRUCTURE-ACTIVITY RELATIONSHIP STUDIES
    LINHARDT, RJ
    DESAI, UR
    LIU, J
    PERVIN, A
    HOPPENSTEADT, D
    FAREED, J
    BIOCHEMICAL PHARMACOLOGY, 1994, 47 (07) : 1241 - 1252
  • [24] Antithrombotic and anticomplementary properties of a very low molecular mass dermatan sulfate
    Alberto, Maria Fabiana
    Romero, Diego Giaquinta
    Lazzari, Maria
    Calabrese, Graciela C.
    THROMBOSIS RESEARCH, 2008, 122 (01) : 109 - 116
  • [25] EXPERIMENTAL STUDIES ON THE RELATIVE EFFICACY OF DERMATAN SULFATE AND HEPARIN AS ANTITHROMBOTIC AGENTS
    MERTON, RE
    THOMAS, DP
    THROMBOSIS AND HAEMOSTASIS, 1987, 58 (03) : 839 - 842
  • [26] Dermatan sulfate proteoglycans from the mineralized matrix of the avian eggshell
    Carrino, DA
    Rodriguez, JP
    Caplan, AI
    CONNECTIVE TISSUE RESEARCH, 1997, 36 (03) : 175 - 193
  • [27] Dermatan sulfate: antithrombotic effects and stimuli of heparan sulfate proteoglycan synthesis from endothelial cells
    Gerheim-Silva, Joao Victor
    Maranduba, Carlos Magno da Costa
    Carpanez, Arthur Girardi
    De Oliveira Guerra, Martha
    Peters, Vera Maria
    Pereira De Medeiros, Valquiria
    Kopke De Aguiar, Jair Adriano
    BIOPHYSICAL REVIEWS, 2021, 13 (06) : 1403 - 1404
  • [28] INVITRO STUDY OF A NEW POTENTIAL ANTITHROMBOTIC DRUG MF 701 (DERMATAN SULFATE)
    TOULON, P
    AIACH, M
    GIANESE, F
    ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1989, 556 : 486 - 488
  • [29] INVITRO STUDY OF A NEW POTENTIAL ANTITHROMBOTIC DRUG MF 701 (DERMATAN SULFATE)
    TOULON, P
    AIACH, M
    GIANESE, F
    HEPARIN AND RELATED POLYSACCHARIDES : STRUCTURE AND ACTIVITIES, 1989, 556 : 486 - 488
  • [30] Dermatan sulfate: Recent structural and activity data
    Volpi, Nicola
    CARBOHYDRATE POLYMERS, 2010, 82 (02) : 233 - 239
12345