Antithrombotic activity of avian crown dermatan sulfate

被引：16
|
作者：
Kyogashima, M
Onaya, J
Miyauchi, S
Arai, M
Shibata, Y
Suda, A
Sakai, T
Takada, Y
Takada, A
机构：
[1] Seikagaku Corp, Tokyo Res Inst, Tokyo 2070021, Japan
[2] Hamamatsu Univ Sch Med, Dept Physiol, Hammatsu, Japan
来源：
THROMBOSIS RESEARCH | 1999年 / 96卷 / 06期
关键词：
avian crown dermatan sulfate; anticoagulant; fibrinolysis; thrombosis;
D O I：
10.1016/S0049-3848(99)00138-3
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The antithrombotic activity of dermatan sulfate from avian crown with the mean molecular weight of 38000 was compared to those from bovine intestine with the mean molecular weight of 16000 in vivo and in vitro. In an in vitro test. bovine intestine dermatan sulfate exhibited stronger effects on stimulation of heparin cofactor II and activation of Glu-plasminogen by tissue plasminogen activator. In vivo, avian crown dermatan sulfate more effectively prevented the development of thrombus in a rat deep vein thrombosis model, The measurement of plasma levels of these two kinds of dermatan sulfate revealed that avian crown dermatan sulfate circulated in higher concentration and longer duration than bovine intestine dermatan sulfate after intravenous administration to rats. (C) 1999 Elsevier Science Ltd. All rights reserved.
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页码：459 / 465
页数：7
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