Genetic variation in the capsid region of human astrovirus serotype 4 isolated in Japan

被引：5
|
作者：
Hachiya, M
Matsui, M
Sanogo, M
Oseto, M
Morooka, K
Ushijima, H
机构：
[1] Univ Tokyo, Grad Sch Med, Inst Internal Hlth, Dept Dev Med Sci,Bunkyo Ku, Tokyo 1130033, Japan
[2] Toho Univ, Sch Med, Dept Pediat 1, Ota Ku, Tokyo 1438541, Japan
[3] Ehime Prefectural Inst Hlth, Matsuyama, Ehime 790003, Japan
来源：
MICROBIOLOGY AND IMMUNOLOGY | 1999年 / 43卷 / 11期
关键词：
astrovirus; serotype; 4; subgroup; RT-PCR; homology;
D O I：
10.1111/j.1348-0421.1999.tb01237.x
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The entire capsid regions of 12 serotype-4 astroviruses from Japan were sequenced and compared with those of other serotypes, Serotype-4 isolates were divided into two new subgroups. The intrasubgroup nucleic acid and deduced amino acid sequences were quite homologous (more than 93%), but slightly less so between subgroups (almost 85%). However, the serotype-a sequences differed from those of serotypes 1, 2, 3, 5, 6, 7 and 8 (less than 50%), Determining whether these differences significantly alter the epidemiology and antigenicity will require further investigation.
引用
收藏
页码：1067 / 1070
页数：4
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