Synthesis and Various Biological Properties of 3-(4-Benzylpiperizino)-1-(4-Ethoxyphenyl)-1-Alkyl(Aryl)-2-Phenylpropan-1-OL Dihydrochlorides

被引：0
|
作者：
Gevorgyan, G. A. [1 ]
Gasparyan, N. K. [1 ]
Papoyan, O. A. [1 ]
Tumadzhyan, A. E. [1 ]
Tatevosyan, A. A. [1 ]
Panosyan, G. A. [1 ]
机构：
[1] Natl Acad Sci Republ Armenia, AL Mndzhoyan Sci Tech Ctr Organ & Pharmaceut Che, 26 Azatutyan Prospekt, Erevan 0014, Armenia
来源：
PHARMACEUTICAL CHEMISTRY JOURNAL | 2017年 / 51卷 / 01期
关键词：
aminomethylation; benzylpiperazinopropanone; benzylpiperazinoalkanols; Grignard reagents; anti-inflammatory; analgesic; antipyretic; peripheral n-cholinolytic activity;
D O I：
10.1007/s11094-017-1552-0
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Aminomethylation of 1-(4-ethoxyphenyl)-2-phenylethanone yielded 3-(4-benzylpiperazin-1-yl)-1-(4-ethoxyphenyl)-2-phenylpropan-1-one. Reduction of this compound with lithium aluminum hydride produced 3-(4-benzylpiperazin-1-yl)-1-(4-ethoxyphenyl)-2-phenylpropan-1-one, and interaction of this with Grignard reagents produced 3-(4-benzylpiperazinyl)-1-(4-ethoxyphenyl)-1-alkyl(aryl)-2-phenylpropan-1-ones. Some of the dihydrochlorides of the resulting compounds were found to have anti-inflammatory, analgesic, and peripheral n-cholinolytic activity.
引用
收藏
页码：30 / 34
页数：5
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