Synthesis and Various Biological Properties of 3-(4-Benzylpiperizino)-1-(4-Ethoxyphenyl)-1-Alkyl(Aryl)-2-Phenylpropan-1-OL Dihydrochlorides

被引：0

作者：

Gevorgyan, G. A. ^{[1
]}

Gasparyan, N. K. ^{[1
]}

Papoyan, O. A. ^{[1
]}

Tumadzhyan, A. E. ^{[1
]}

Tatevosyan, A. A. ^{[1
]}

Panosyan, G. A. ^{[1
]}

机构：

[1] Natl Acad Sci Republ Armenia, AL Mndzhoyan Sci Tech Ctr Organ & Pharmaceut Che, 26 Azatutyan Prospekt, Erevan 0014, Armenia

来源：

PHARMACEUTICAL CHEMISTRY JOURNAL | 2017年 / 51卷 / 01期

关键词：

aminomethylation; benzylpiperazinopropanone; benzylpiperazinoalkanols; Grignard reagents; anti-inflammatory; analgesic; antipyretic; peripheral n-cholinolytic activity;

D O I：

10.1007/s11094-017-1552-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Aminomethylation of 1-(4-ethoxyphenyl)-2-phenylethanone yielded 3-(4-benzylpiperazin-1-yl)-1-(4-ethoxyphenyl)-2-phenylpropan-1-one. Reduction of this compound with lithium aluminum hydride produced 3-(4-benzylpiperazin-1-yl)-1-(4-ethoxyphenyl)-2-phenylpropan-1-one, and interaction of this with Grignard reagents produced 3-(4-benzylpiperazinyl)-1-(4-ethoxyphenyl)-1-alkyl(aryl)-2-phenylpropan-1-ones. Some of the dihydrochlorides of the resulting compounds were found to have anti-inflammatory, analgesic, and peripheral n-cholinolytic activity.

引用

页码：30 / 34

页数：5

共 50 条

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