Structure-activity relationships of orally active antimalarial acridones: Synthesis, optimization, and biological activity

被引：0
|
作者：
Kelly, Jane X. [1 ]
Smilkstein, Martin [1 ]
Winter, Rolf [1 ]
Dodean, Rosie [1 ]
Riscoe, Mike [1 ]
机构：
[1] Portland VA Med Ctr, Portland, OR USA
来源：
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE | 2006年 / 75卷 / 05期
关键词：
D O I：
暂无
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
872
引用
收藏
页码：251 / 251
页数：1
相关论文
共 50 条
  • [1] Antimalarial activity and structure-activity relationships of protoberberine alkaloids
    Iwasa, K
    Kim, HS
    Wataya, Y
    Lee, DU
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 1998, 33 (01) : 65 - 69
  • [2] Synthesis and Insight into the Structure-Activity Relationships of Chalcones as Antimalarial Agents
    Tadigoppula, Narender
    Korthikunta, Venkateswarlu
    Gupta, Shweta
    Kancharla, Papireddy
    Khaliq, Tanvir
    Soni, Awakash
    Srivastava, Rajeev Kumar
    Srivastava, Kumkum
    Puri, Sunil Kumar
    Raju, Kanumuri Siva Rama
    Wahajuddin
    Sijwali, Puran Singh
    Kumar, Vikash
    Mohammad, Imran Siddiqi
    JOURNAL OF MEDICINAL CHEMISTRY, 2013, 56 (01) : 31 - 45
  • [3] Synthesis and structure-activity relationships of potent and orally active sulfonamide ETB selective antagonists
    Kanda, Y
    Kawanishi, Y
    Oda, K
    Sakata, T
    Mihara, S
    Asakura, K
    Kanemasa, T
    Ninomiya, M
    Fujimoto, M
    Konoike, T
    BIOORGANIC & MEDICINAL CHEMISTRY, 2001, 9 (04) : 897 - 907
  • [4] Antimalarial N1,N3-Dialkyldioxonaphthoimidazoliums: Synthesis, Biological Activity, and Structure-activity Relationships
    Ahenkorah, Stephen
    Coertzen, Dina
    Tong, Jie Xin
    Fridianto, Kevin
    Wittlin, Sergio
    Birkholtz, Lyn-Marie
    Tan, Kevin S. W.
    Lam, Yulin
    Go, Mei-Lin
    Haynes, Richard K.
    ACS MEDICINAL CHEMISTRY LETTERS, 2020, 11 (01): : 49 - 55
  • [5] Structure-activity relationships of antileishmanial and antimalarial chalcones
    Liu, M
    Wilairat, P
    Croft, SL
    Tan, ALC
    Go, ML
    BIOORGANIC & MEDICINAL CHEMISTRY, 2003, 11 (13) : 2729 - 2738
  • [6] Structure-activity relationships of quaternary protoberberine alkaloids having an antimalarial activity
    Iwasa, K
    Nishiyama, Y
    Ichimaru, M
    Moriyasu, M
    Kim, HS
    Wataya, Y
    Yamori, T
    Takashi, T
    Lee, DU
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 1999, 34 (12) : 1077 - 1083
  • [7] Structure-Activity Relationship Studies of Orally Active Antimalarial 2,4-Diamino-thienopyrimidines
    Cabrera, Diego Gonzalez
    Douelle, Frederic
    Le Manach, Claire
    Han, Ze
    Paquet, Tanya
    Taylor, Dale
    Njoroge, Mathew
    Lawrence, Nina
    Wiesner, Lubbe
    Waterson, David
    Witty, Michael J.
    Wittlin, Sergio
    Street, Leslie J.
    Chibale, Kelly
    JOURNAL OF MEDICINAL CHEMISTRY, 2015, 58 (18) : 7572 - 7579
  • [8] Orally active acridones as novel and potent antimalarial chemotypes
    Kelly, Jane X.
    Smilkstein, Martin
    Winter, Rolf
    Doclean, Rosie
    Hinrichs, Dave
    Riscoe, Mike
    AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2006, 75 (05): : 250 - 251
  • [9] Synthesis and structure-activity relationships of novel benzoxaboroles as a new class of antimalarial agents
    Zhang, Yong-Kang
    Plattner, Jacob J.
    Freund, Yvonne R.
    Easom, Eric E.
    Zhou, Yasheen
    Gut, Jiri
    Rosenthal, Philip J.
    Waterson, David
    Gamo, Francisco-Javier
    Angulo-Barturen, Inigo
    Ge, Min
    Li, Zhiya
    Li, Lingchao
    Jian, Yong
    Cui, Han
    Wang, Hailong
    Yang, Jian
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2011, 21 (02) : 644 - 651
  • [10] Structure-activity relationships of novel, highly potent, selective, and orally active CCRI antagonists
    Xie, Yun Feng
    Lake, Kirk
    Ligsay, Kathleen
    Komandla, Mallareddy
    Sircar, Ila
    Nagarajan, Gobi
    Li, Jian
    Xu, Kui
    Parise, Jason
    Schneider, Lisa
    Huang, Ding
    Liu, Juping
    Dines, Kevin
    Sakurai, Naoki
    Barbosa, Miguel
    Jack, Rick
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2007, 17 (12) : 3367 - 3372
12345