cGAS-independent STING activation in response to DNA damage

被引：27
|
作者：
Unterholzner, Leonie [1 ]
Dunphy, Gillian [1 ]
机构：
[1] Univ Lancaster, Fac Hlth & Med, Div Biomed & Life Sci, Lancaster, England
来源：
MOLECULAR & CELLULAR ONCOLOGY | 2019年 / 6卷 / 04期
基金：
英国医学研究理事会;
关键词：
DNA damage; innate immunity; etoposide; STING; IFI16; IFI16;
D O I：
10.1080/23723556.2018.1558682
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Self-DNA has previously been thought to be protected from immune detection by compartmentalisation in the nucleus or mitochondria. Here, we describe the discovery of a signalling cascade that links the detection of DNA damage in the nucleus to the activation of the innate immune adaptor STING (STimulator of INterfern Genes).
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页数：3
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