Bactericidal Activity of the Combination of Levofloxacin with Rifampin in Experimental Prosthetic Knee Infection in Rabbits Due to Methicillin-Susceptible Staphylococcus aureus

被引：13
|
作者：
Muller-Serieys, Claudette [1 ]
Mghir, Azzam Saleh [2 ]
Massias, Laurent [3 ]
Fantin, Bruno [2 ]
机构：
[1] Hop Bichat Claude Bernard, AP HP, Microbiol Lab, F-75877 Paris, France
[2] Univ Paris Diderot, EA3964, Paris, France
[3] Hop Bichat Claude Bernard, AP HP, Serv Pharm, Lab Toxicol Pharmacocinet, F-75877 Paris, France
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2009年 / 53卷 / 05期
关键词：
FOREIGN-BODY INFECTION; JOINT INFECTION; ANIMAL-MODELS; MOXIFLOXACIN; EFFICACY; THERAPY;
D O I：
10.1128/AAC.01163-08
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The combination of levofloxacin and rifampin has been recommended for the treatment of staphylococcal prosthetic infection. In a rabbit model of prosthetic knee infection due to a susceptible clinical strain of Staphylococcus aureus, the combination of levofloxacin and rifampin was bactericidal, significantly reduced bacterial titers in bone compared with levels for rifampin and controls (P < 0.05), sterilized 6 of 12 animals, and prevented the selection of resistant mutants that was observed with rifampin alone, validating clinical recommendations.
引用
收藏
页码：2145 / 2148
页数：4
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