Synthesis and Bioactivity of Some New 2-(Alkoxy carbonyl alkyl)-6-bromo-3,4-dihydro-3-(α-methyl benzyl)-2-oxo-benzo[e] [2H-1,3,2-oxazaphosphinine] Derivatives

被引：2
|
作者：
Srinivasulu, K. [1 ]
Kumar, Suresh K. [1 ]
Babu, Hari B. [1 ]
Babu, Stephen M. F. [1 ]
Raju, Naga C. [1 ]
Reddy, Suresh C. [1 ]
机构：
[1] Sri Venkateswara Univ, Dept Chem, Tirupati 517502, Andhra Pradesh, India
来源：
CHINESE JOURNAL OF CHEMISTRY | 2009年 / 27卷 / 04期
关键词：
2-[(alpha-methylbenzyl amino)methyl]-4-bromophenol; triethylamine; aminoacid ester; 1,3,2-oxazaphosphinine; AMINO-ACIDS;
D O I：
10.1002/cjoc.200990135
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Synthesis of some new 2-(alkoxy carbonyl alkyl)-6-bromo-3,4-dihydro-3-(alpha-methyl benzyl)-2-oxo-3-benzo[e][2H-1,3,2-oxazaphosphinine] derivatives was accomplished through a two step process, which involves the condensation of 2-[(a-methylbenzyl amino)methyl]-4-bromophenol (1) with phosphorus oxychloride in equimolar quantities in the presence of triethylamine in dry toluene in 50-55 degrees C producing the corresponding intermediate (2), and subsequent reaction with the amino acid alkyl ester in dry tetrahydrofuran in the presence of triethylamine at different temperatures. They exhibited significant antibacterial and fungal activity.
引用
收藏
页码：810 / 814
页数：5
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