A low-cost miniaturized potentiostat for point-of-care diagnosis

被引:126
|
作者
Cruz, Andres Felipe Diaz [1 ]
Norena, Nicolas [1 ]
Kaushik, Ajeet [2 ]
Bhansali, Shekhar [1 ]
机构
[1] Florida Int Lab, BioMEMS Microsyst Lab, Miami, FL 33174 USA
[2] Florida Int Univ, Herbert Wertheim Coll Med, Inst Neuroimmune Pharmacol, Ctr Personalized Nanomed,Dept Immunol, Miami, FL 33199 USA
来源
BIOSENSORS & BIOELECTRONICS | 2014年 / 62卷
关键词
Miniaturized potentiostat; Point-of-care; Personalized health monitoring/diagnostic; Electrochemical immunosensing; Cortisol; INTERDIGITATED ARRAY MICROELECTRODES; PORTABLE POTENTIOSTAT; LABEL-FREE; BIOSENSORS; TECHNOLOGIES; SENSORS; SYSTEMS; DESIGN;
D O I
10.1016/j.bios.2014.06.053
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
This paper presents a novel approach of using a miniaturized potentiostat (M-P) chip (LMP91000) to perform full range cyclic voltammetry (CV) measurements for the detection of biomarkers. The LMP91000 evaluation board was reconfigured to perform three-electrode CV measurements in order to achieve electrochemical cortisol immunosensing. The microelectrodes for cortisol estimation were fabricated by immobilizing monoclonal anti-cortisol antibody (Anti-M-Cab) onto self-assembled monolayer (SAM) modified Au microelectrodes. The results obtained using the M-P were compared to those obtained using a conventional potentiostat. The M-P was successful in measuring cortisol levels in the range of pM. The outcomes of the studies suggest that M-P can effectively perform biochemical measurements on three electrode systems, enabling the development of miniature systems for point-of-care (POC) diagnosis. (C) 2014 Published by Elsevier B.V.
引用
收藏
页码:249 / 254
页数:6
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