Phosphorylation keeps PTEN phosphatase closed for business

被引:67
|
作者
Ross, Alonzo H. [1 ]
Gericke, Arne [2 ]
机构
[1] Univ Massachusetts, Sch Med, Dept Mol Pharmacol & Biochem, Worcester, MA 01605 USA
[2] Kent State Univ, Dept Chem, Kent, OH 44242 USA
关键词
TUMOR-SUPPRESSOR; ACTIVATION; BINDING; MECHANISM; ACTS;
D O I
10.1073/pnas.0812473106
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
引用
下载
收藏
页码:1297 / 1298
页数:2
相关论文
共 50 条
  • [11] Phosphorylation of PTEN (phosphatase and tensin homologue deleted on chromosome ten) protein is enhanced in human fibromyomatous uteri
    Kovacs, Kalman A.
    Lengyel, Ferenc
    Vertes, Zsuzsanna
    Kornyei, Jozsef L.
    Gocze, Peter M.
    Sumegi, Balazs
    Szabo, Istvan
    Vertes, Marietta
    JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2007, 103 (02): : 196 - 199
  • [12] Phosphorylation mediated conformational changes defines nuclear role of phosphatase and tensin homology (PTEN) in tumor suppression
    Malaney, Prerna
    Semidey-Hurtado, Jonathan
    Hardee, Jamaal
    Patel, Deepal
    Hennessey, Daniel
    Stanford, Kate
    Palumbo, Emily
    Tian, Zhi
    Allen-Gipson, Diane
    Dave, Vrushank
    CANCER RESEARCH, 2016, 76
  • [13] BUSINESS KEEPS ITS SPIRITS UP
    BROWNSTEIN, V
    FORTUNE, 1992, 126 (04) : 21 - &
  • [15] Cooperative phosphorylation of the tumor suppressor phosphatase and tensin homologue (PTEN) by casein kinases and glycogen synthase kinase 3β
    Al-Khouri, AM
    Ma, YL
    Togo, SH
    Williams, S
    Mustelin, T
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (42) : 35195 - 35202
  • [16] Both phosphorylation and phosphatase activity of PTEN are required to prevent replication fork progression during stress by inducing heterochromatin
    Misra, Sandip
    Chowdhury, Sougata Ghosh
    Ghosh, Ginia
    Mukherjee, Ananda
    Karmakar, Parimal
    MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 2022, 825
  • [17] Both phosphorylation and phosphatase activity of PTEN are required to prevent replication fork progression during stress by inducing heterochromatin
    Misra, Sandip
    Chowdhury, Sougata Ghosh
    Ghosh, Ginia
    Mukherjee, Ananda
    Karmakar, Parimal
    MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 2022, 825
  • [18] Regulation of NMDA receptors by the phosphatase PTEN
    Ning, K.
    Wan, Q.
    JOURNAL OF NEUROCHEMISTRY, 2007, 102 : 147 - 147
  • [19] Importin-11 keeps PTEN safe from harm
    Leslie, Nick R.
    JOURNAL OF CELL BIOLOGY, 2017, 216 (03): : 539 - 541
  • [20] CLOSED FOR BUSINESS
    Wang, Linda
    CHEMICAL & ENGINEERING NEWS, 2009, 87 (49) : 28 - 29