AN EFFICIENT ONE-POT SYNTHESIS OF NEW 2-THIOXO AND 2-OXO-PYRIMIDINE-5-CARBONITRILES IN BALL-MILLING UNDER SOLVENT-FREE AND CATALYST-FREE CONDITIONS

被引：11
|
作者：
M'hamed, Mohamed Ould [1 ]
Alduaij, Omar K. [1 ]
机构：
[1] Al Imam Mohammad Ibn Saud Islamic Univ IMSIU, Dept Chem, Coll Sci, Riyadh 11623, Saudi Arabia
来源：
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 2014年 / 189卷 / 02期
关键词：
Ball milling solvent-free reaction; catalyst-free; thioxo-pyrimidine; oxo-pyrimidine; SOLID-STATE; WASTE-FREE; MECHANOCHEMISTRY; PYRIMIDINE;
D O I：
10.1080/10426507.2013.818995
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Various 2-thioxo and 2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carbonitriles were synthesized in very high yields in 40min through a direct condensation of an equimolar amount of an aldehyde, malononitrile, and thiourea/urea under ball mill solvent-free and catalyst-free conditions.
引用
收藏
页码：235 / 241
页数：7
相关论文
共 50 条
  • [31] A One-Pot, Multicomponent Synthesis of Trifluoromethylated Spiropiperidines under Catalyst-Free Conditions
    Shi, Wei
    Wang, Yang
    Zhu, Yingjun
    Zhang, Min
    Song, Liping
    Deng, Hongmei
    SYNTHESIS-STUTTGART, 2016, 48 (20): : 3527 - 3536
  • [32] Solvent- and catalyst-free synthesis of dihydropyrimidinthiones in one-pot under focused microwave irradiation conditions
    Zhan, Hong Wen
    Wang, Jin Xian
    Wang, Xi Tian
    CHINESE CHEMICAL LETTERS, 2008, 19 (10) : 1183 - 1185
  • [33] Solvent- and catalyst-free synthesis of dihydropyrimidinthiones in one-pot under focused microwave irradiation conditions
    Hong Wen Zhan Jin Xian Wang~* Xi Tian Wang Institute of Chemistry
    ChineseChemicalLetters, 2008, (10) : 1183 - 1185
  • [34] An Alternative Solvent-Free Synthesis of Nopinone under Ball-Milling Conditions: Investigation of Reaction Parameters
    Szuppa, Tony
    Stolle, Achim
    Ondruschka, Bernd
    Hopfe, Wieland
    CHEMSUSCHEM, 2010, 3 (10) : 1181 - 1191
  • [35] A ball-milling strategy for the synthesis of benzothiazole, benzimidazole and benzoxazole derivatives under solvent-free conditions
    Sharma, Hemant
    Singh, Narinder
    Jang, Doo Ok
    GREEN CHEMISTRY, 2014, 16 (12) : 4922 - 4930
  • [36] An Efficient One-Pot, Three-Component Synthesis of Tetrasubstituted Pyrroles under Catalyst- and Solvent-Free Conditions
    Karthiyayini, Gnanaoli
    Rajkumar, Deepan Babu
    Nagarajan, Subbiah
    Sridharan, Vellaisamy
    Maheswari, C. Uma
    SYNLETT, 2023, 34 (16) : 1930 - 1938
  • [37] An efficient one-pot synthesis of 3-aryl-1,2,4-oxadiazol-5-amines under solvent-free conditions
    Adib, Mehdi
    Bagherzadeh, Sharareh
    Mahdavi, Mohammad
    Bijanzadeh, Hamid R.
    MENDELEEV COMMUNICATIONS, 2010, 20 (01) : 50 - 51
  • [38] An efficient one-pot synthesis of dihydropyrano[c]chromenes and amino-2-chromenes under solvent-free conditions
    Habibi, Davood
    Shamsian, Atefeh
    JOURNAL OF CHEMICAL RESEARCH, 2013, (04) : 253 - 255
  • [39] A new, efficient, and simple method for the one-pot synthesis of α-acetoxyphosphonates from aldehydes under solvent-free conditions
    Kaboudin, Babak
    Karimi, Masoumeh
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2006, 16 (20) : 5324 - 5327
  • [40] Catalyst-free three-component synthesis of 2-amino-4,6-diarylpyridine-3-carbonitriles under solvent-free conditions
    Mohammad Hosein Sayahi
    Seyyed Jafar Saghanezhad
    Mohammad Mahdavi
    Chemistry of Heterocyclic Compounds, 2019, 55 : 725 - 728
12345