Replication-selective microbiological agents: fighting cancer with targeted germ warfare

被引:47
|
作者
Kirn, DH [1 ]
机构
[1] Hammersmith Hosp, Imperial Coll Sch Med, Program Viral & Genet Therapy Canc, Imperial Canc Res Fund,Mol Oncol Unit, London W12 0NN, England
来源
JOURNAL OF CLINICAL INVESTIGATION | 2000年 / 105卷 / 07期
关键词
D O I
10.1172/JCI9761
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
[No abstract available]
引用
收藏
页码:837 / 839
页数:3
相关论文
共 46 条
  • [21] An E2F-responsive replication-selective adenovirus targeted to the defective cell cycle in cancer cells: Potent antitumoral efficacy but no toxicity to normal cell
    Tsukuda, K
    Wiewrodt, R
    Molnar-Kimber, K
    Jovanovic, VP
    Amin, KM
    CANCER RESEARCH, 2002, 62 (12) : 3438 - 3447
  • [22] Intravenous infusion of a replication-selective adenovirus (ONYX-015) in cancer patients: safety, feasibility and biological activity
    J Nemunaitis
    C Cunningham
    A Buchanan
    A Blackburn
    G Edelman
    P Maples
    G Netto
    A Tong
    B Randlev
    S Olson
    D Kirn
    Gene Therapy, 2001, 8 : 746 - 759
  • [23] Intravenous infusion of a replication-selective adenovirus (ONYX-015) in cancer patients: safety, feasibility and biological activity
    Nemunaitis, J
    Cunningham, C
    Buchanan, A
    Blackburn, A
    Edelman, G
    Maples, P
    Netto, G
    Tong, A
    Randlev, B
    Olson, S
    Kirn, D
    GENE THERAPY, 2001, 8 (10) : 746 - 759
  • [24] A phase 1/11 trial of IVCG7870, a replication-selective, PSA-targeted oncolytic adenovirus (OAV), for the treatment of hormone-refractory, metastatic prostate cancer
    Wilding, G
    Carducci, M
    Yu, DC
    Burke, J
    Borellini, F
    Aimi, J
    Working, P
    Ando, D
    Kirn, D
    Small, E
    JOURNAL OF CLINICAL ONCOLOGY, 2004, 22 (14) : 204S - 204S
  • [25] Virus-mediated oncolysis of thyroid cancer by a replication-selective adenovirus driven by a thyroglobulin promoter-enhancer region
    Kesmodel, S
    Prabakaran, I
    Canter, R
    Menon, C
    Molnar-Kimber, K
    Fraker, D
    JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2005, 90 (06): : 3440 - 3448
  • [26] Gene therapy for pancreatic cancer targeting the genomic alterations of tumor suppressor genes using replication-selective oncolytic adenovirus
    Sunamura M.
    Oonuma M.
    Motoi F.
    Abe H.
    Saitoh Y.
    Hoshida T.
    Ottomo S.
    Horii A.
    Matsuno S.
    Human Cell, 2002, 15 (3) : 138 - 150
  • [27] A novel approach using telomerase-specific replication-selective adenovirus for detection of circulating tumor cells in breast cancer patients
    Seung Jin Kim
    Akinori Masago
    Yasuhiro Tamaki
    Kenji Akazawa
    Fumine Tsukamoto
    Jun Sato
    Toshiyuki Ozawa
    Yukio Tsujino
    Shinzaburo Noguchi
    Breast Cancer Research and Treatment, 2011, 128 : 765 - 773
  • [28] A novel approach using telomerase-specific replication-selective adenovirus for detection of circulating tumor cells in breast cancer patients
    Kim, Seung Jin
    Masago, Akinori
    Tamaki, Yasuhiro
    Akazawa, Kenji
    Tsukamoto, Fumine
    Sato, Jun
    Ozawa, Toshiyuki
    Tsujino, Yukio
    Noguchi, Shinzaburo
    BREAST CANCER RESEARCH AND TREATMENT, 2011, 128 (03) : 765 - 773
  • [29] Replication-selective herpes simplex virus type 1 mutant therapy of cervical cancer is enhanced by low-dose radiation
    Blank, SV
    Rubin, SC
    Coukos, G
    Amin, KM
    Albelda, SM
    Molnar-Kimber, KL
    HUMAN GENE THERAPY, 2002, 13 (05) : 627 - 639
  • [30] Phase II trial of intratumoral administration of ONYX-015, a replication-selective adenovirus, in patients with refractory head and neck cancer
    Nemunaitis, J
    Khuri, F
    Ganly, I
    Arseneau, J
    Posner, M
    Vokes, E
    Kuhn, J
    McCarty, T
    Landers, S
    Blackburn, A
    Romel, L
    Randlev, B
    Kaye, S
    Kirn, D
    JOURNAL OF CLINICAL ONCOLOGY, 2001, 19 (02) : 289 - 298