AAV-2 capsid-specific CD8+T cells limit the duration of gene therapy in humans and cross-react with AAV-8 capsid.

被引:0
|
作者
Mingozzi, Federico
Maus, Marcela V.
Sabatino, Denise E.
Hui, Daniel J.
Rasko, John E. J.
Ragni, Margaret V.
Manno, Catherine Scott
Ertl, Hildegund C. J.
High, Katherine A.
机构
[1] Childrens Hosp Philadelphia, Philadelphia, PA 19104 USA
[2] Univ Sydney, Cent Inst Canc Med & Cell Biol, Newtown, Tas, Australia
[3] Univ Penn, Med Ctr, Hemophillia Ctr W Pennsylvania, Pittsburgh, PA USA
[4] Wistar Inst Anat & Biol, Program Immunol, Philadelphia, PA 19104 USA
[5] Howard Hughes Med Inst, Philadelphia, PA USA
关键词
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
455
引用
收藏
页码:138A / 139A
页数:2
相关论文
共 40 条
  • [1] AAV Capsid-Specific CD8+T Cells and Their Responsiveness to Hepatic AAV Gene Transfer
    Li, Hua
    High, Katherine
    Ertl, Hildegund C. J.
    [J]. MOLECULAR THERAPY, 2009, 17 : S313 - S313
  • [2] Localization of Structural Determinants in AAV Capsid for Efficient Liver Transduction by Domain Swapping between AAV-2 and AAV-8
    Shen, Xuan
    Xu, Hui
    Storm, Theresa
    Kay, Mark A.
    [J]. MOLECULAR THERAPY, 2006, 13 : S288 - S288
  • [3] Identification of mouse AAV capsid-specific CD8+ T cell epitopes
    Sabatino, DE
    Mingozzi, F
    Hui, DJ
    Chen, HF
    Colosi, P
    Ertl, HCJ
    High, KA
    [J]. MOLECULAR THERAPY, 2005, 12 (06) : 1023 - 1033
  • [4] Plasmacytoid and conventional dendritic cells cooperate in crosspriming AAV capsid-specific CD8+ T cells
    Rogers, Geoffrey L.
    Shirley, Jamie L.
    Zolotukhin, Irene
    Kumar, Sandeep R. P.
    Sherman, Alexandra
    Perrin, George Q.
    Hoffman, Brad E.
    Srivastava, Arun
    Basner-Tschakarjan, Etiena
    Wallet, Mark A.
    Terhorst, Cox
    Biswas, Moanaro
    Herzog, Roland W.
    [J]. BLOOD, 2017, 129 (24) : 3184 - 3195
  • [5] Pre-existing AAV capsid-specific CD8+ T cells are unable to eliminate AAV-transduced hepatocytes
    Li, Hua
    Murphy, Samuel L.
    Giles-Davis, Wynetta
    Edmonson, Shyrie
    Xiang, Zhiquan
    Li, Yan
    Lasaro, Marcio O.
    High, Katherine A.
    Ertl, Hildegund C. J.
    [J]. MOLECULAR THERAPY, 2007, 15 (04) : 792 - 800
  • [6] Engineered AAV vector minimizes in vivo targeting of transduced hepatocytes by capsid-specific CD8+ T cells
    Martino, Ashley T.
    Basner-Tschakarjan, Etiena
    Markusic, David M.
    Finn, Jonathan D.
    Hinderer, Christian
    Zhou, Shangzhen
    Ostrov, David A.
    Srivastava, Arun
    Ertl, Hildegund C. J.
    Terhorst, Cox
    High, Katherine A.
    Mingozzi, Federico
    Herzog, Roland W.
    [J]. BLOOD, 2013, 121 (12) : 2224 - 2233
  • [7] The Effect of CpG Sequences on Capsid-Specific CD8+ T Cell Responses to AAV Vector Gene Transfer
    Xiang, ZhiQuan
    Kurupati, Raj K.
    Li, Yan
    Kuranda, Klaudia
    Zhou, Xiangyang
    Mingozzi, Federico
    High, Katherine A.
    Ertl, Hildegund C. J.
    [J]. MOLECULAR THERAPY, 2020, 28 (03) : 771 - 783
  • [8] In Vivo Model to Evaluate Loss of Liver-Derived Factor IX Expression Caused by AAV Capsid-Specific CD8+T Cells
    Markusic, David M.
    Martino, Ashley T.
    Mingozzi, Federico
    High, Katherine A.
    Herzog, Roland W.
    [J]. BLOOD, 2012, 120 (21)
  • [9] Effect of CpG Depletion on Anti-Capsid CD8+T Cell Priming to AAV Gene Therapy
    Bertolini, Thais
    Shirley, Jamie
    Zolotukhin, Irene
    Kumar, Sandeep
    Herzog, Roland
    [J]. MOLECULAR THERAPY, 2020, 28 (04) : 22 - 23
  • [10] Direct Type I Interferon Signaling in Conventional Dendritic Cells and T Help are Required for Cross-Priming AAV Capsid-Specific CD8+ T Cells
    Shirley, Jamie L.
    Herzog, Roland W.
    [J]. MOLECULAR THERAPY, 2019, 27 (04) : 77 - 77