Formal total synthesis of (+)-zaragozic acid C through an Ireland-Claisen rearrangement

被引：31

作者：

Bunte, Jens O. ^{[1
]}

Cuzzupe, Anthony N. ^{[1
]}

Daly, Alica M. ^{[1
]}

Rizzacasa, Mark A. ^{[1
]}

机构：

[1] Univ Melbourne, Sch Chem, Inst Bio21, Melbourne, Vic 3010, Australia

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 38期

关键词：

Ireland-Claisen rearrangement; lactones; natural products; total synthesis; zaragozic acid;

D O I：

10.1002/anie.200602507

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) A simple rearrangement: A formal total synthesis of zaragozic acid C (1) was achieved by the synthesis of intermediate 2. The key step involves an Ireland-Claisen rearrangement of an allylic ester to generate a carbon-carbon bond and two asymmetric centers simultaneously. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：6376 / 6380

页数：5

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