Convenient palladium-catalyzed preparation of primary anilines using a fluorous benzophenone imine reagent

被引：33
|
作者：
Cioffi, CL [1 ]
Berlin, ML [1 ]
Herr, RJ [1 ]
机构：
[1] Albany Mol Res Inc, Dept Med Chem, Albany, NY 12212 USA
来源：
SYNLETT | 2004年 / 05期
关键词：
amination; arylation; cross-coupling; palladium-catalyzed; fluorous;
D O I：
10.1055/s-2004-820011
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel fluoroalkyl benzophenone imine reagent (f-BPI) serves as a convenient ammonia surrogate for the palladium-catalyzed Buchwald-Hartwig amination of aryl halides. The highly fluorinated imine moiety acts as a handle for rapid purification of intermediates using fluorous chromatographic techniques, and is removed in a subsequent stage by acid hydrolysis to provide the corresponding primary anilines.
引用
收藏
页码：841 / 845
页数：5
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