3D structural information as a guide to protein engineering using genetic selection

被引：33
|
作者：
Kast, P [1 ]
Hilvert, D [1 ]
机构：
[1] Scripps Res Inst, DEPT CHEM, LA JOLLA, CA 92037 USA
来源：
CURRENT OPINION IN STRUCTURAL BIOLOGY | 1997年 / 7卷 / 04期
关键词：
D O I：
10.1016/S0959-440X(97)80109-1
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A great variety of protein systems have been investigated in the past year using structure-guided evolutionary strategies. On the basis of available 3D structural information, critical regions of proteins have been targeted for randomizing mutagenesis and active variants of the corresponding genes have been selected. These approaches help characterize structural and mechanistic features of proteins and have important implications far design.
引用
收藏
页码：470 / 479
页数：10
相关论文
共 50 条
  • [1] USING STRUCTURAL COMPARISON AS A GUIDE IN PROTEIN ENGINEERING
    BOTT, R
    DAUBERMAN, J
    CALDWELL, R
    MITCHINSON, C
    WILSON, L
    SCHMIDT, B
    SIMPSON, C
    POWER, S
    LAD, P
    SAGAR, IH
    GRAYCAR, T
    ESTELL, D
    ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1992, 672 : 10 - 19
  • [2] The RCSB protein data bank: integrative view of protein, gene and 3D structural information
    Rose, Peter W.
    Prlic, Andreas
    Altunkaya, Ali
    Bi, Chunxiao
    Bradley, Anthony R.
    Christie, Cole H.
    Di Costanzo, Luigi
    Duarte, Jose M.
    Dutta, Shuchismita
    Feng, Zukang
    Green, Rachel Kramer
    Goodsell, David S.
    Hudson, Brian
    Kalro, Tara
    Lowe, Robert
    Peisach, Ezra
    Randle, Christopher
    Rose, Alexander S.
    Shao, Chenghua
    Tao, Yi-Ping
    Valasatava, Yana
    Voigt, Maria
    Westbrook, John D.
    Woo, Jesse
    Yang, Huangwang
    Young, Jasmine Y.
    Zardecki, Christine
    Berman, Helen M.
    Burley, Stephen K.
    NUCLEIC ACIDS RESEARCH, 2017, 45 (D1) : D271 - D281
  • [3] 3D protein classification using topological, geometrical and biological information
    Tsatsaias, V.
    Daras, P.
    Strintzis, M. G.
    2007 IEEE INTERNATIONAL CONFERENCE ON IMAGE PROCESSING, VOLS 1-7, 2007, : 3333 - +
  • [4] 3D INFORMATION MANAGEMENT ENABLING MANUFACTURE ENGINEERING
    Ali, Salam
    Durupt, Alexandre
    Adragna, Pierre Antoine
    Troussier, Nadege
    PROCEEDINGS OF THE ASME 11TH BIENNIAL CONFERENCE ON ENGINEERING SYSTEMS DESIGN AND ANALYSIS, 2012, VOL 3, 2012, : 513 - 520
  • [5] 3D Concrete Printing - A Structural Engineering Perspective
    Salet, Theo A. M.
    Bos, Freek P.
    Wolfs, Rob J. M.
    Ahmed, Zeeshan Y.
    HIGH TECH CONCRETE: WHERE TECHNOLOGY AND ENGINEERING MEET, 2018, : XLIII - LVII
  • [6] Integrating 3D structural information into systems biology
    Murray, Diana
    Petrey, Donald
    Honig, Barry
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2021, 296
  • [7] Engineering 3D protein scaffolds for biocatalysts assembly
    Chen, Qi
    Sun, Qing
    Wang, Szu-Wen
    Chen, Wilfred
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2014, 247
  • [8] Cognitive Workload Demands Using 2D and 3D Spatial Engineering Information Formats
    Dadi, Gabriel B.
    Goodrum, Paul M.
    Taylor, Timothy R. B.
    Carswell, C. Melody
    JOURNAL OF CONSTRUCTION ENGINEERING AND MANAGEMENT, 2014, 140 (05)
  • [9] 3D protein peptide chain search using an improved genetic algorithm
    Yang, ZL
    Liu, GR
    COMPUTATIONAL SCIENCE AND ITS APPLICATIONS - ICCSA 2003, PT 1, PROCEEDINGS, 2003, 2667 : 322 - 329
  • [10] Automatic ROI Selection in Structural Brain MRI Using SOM 3D Projection
    Ortiz, Andres
    Gorriz, Juan M.
    Ramirez, Javier
    Martinez-Murcia, Francisco J.
    PLOS ONE, 2014, 9 (04):
12345