A chemoenzymatic asymmetric synthesis of (9S,12S,13S)- and (9S,12RS,13S)-pinellic acids

被引：16
|
作者：
Sharma, Anubha [1 ]
Mahato, Seema [1 ]
Chattopadhyay, Subrata [1 ]
机构：
[1] Bhabha Atom Res Ctr, Div Bioorgan, Bombay 400085, Maharashtra, India
来源：
TETRAHEDRON LETTERS | 2009年 / 50卷 / 35期
关键词：
ANTIINFLUENZA VIRUS ACTIVITY; SHO-SEIRYU-TO; NASAL INFLUENZA VACCINE; PINELLIC ACID; ENANTIOSELECTIVE SYNTHESIS; (-)-PINELLIC ACID; ADJUVANT ACTIVITY; ORAL ADJUVANT; LACTONE; MODEL;
D O I：
10.1016/j.tetlet.2009.06.069
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A brief and facile synthesis of the title compounds has been developed by using an efficient lipase-catalyzed acylation and a chiral template-directed diastereoselective alkylation for incorporating the stereogenic centres. A cross-metathesis was employed to get the required E-olefin geometry. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4986 / 4988
页数：3
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