Facile Synthesis of Dihydroquinolines via Palladium Catalyzed Sequential Amination and Cyclisation of Morita-Baylis-Hillman Alcohols

被引：2

作者：

Sruthi, Pambingal Rajan ^{[1
]}

Sankar, P. Uma ^{[2
]}

Saranya, Thachora Venu ^{[1
]}

Anas, Saithalavi ^{[1
,3
]}

机构：

[1] Mahatma Gandhi Univ, Sch Chem Sci, Kottayam, Kerala, India

[2] Amrithaviswavidyapeet, Dept Chem, Kollam, Kerala, India

[3] Mahatma Gandhi Univ, Inst Integrated Programmes & Res Basic Sci IIRBS, Kottayam 686560, Kerala, India

来源：

CHEMISTRYSELECT | 2020年 / 5卷 / 43期

关键词：

Allylicamination; Cyclization; Morita-Baylis-Hillman; Palladium; Quinoline; INTRAMOLECULAR ALLYLIC AMINATION; SUBSTITUTED QUINOLINES; ACETATES; ANNULATION;

D O I：

10.1002/slct.202003413

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Quinolines and its derivatives are significant class of heterocyclic compounds which are identified as the key component in many natural products and biologically important molecules. We describe herein a facile method for the synthesis of quinoline derivatives from Morita-Baylis-Hillman (MBH) Alcohols via Palladium Catalyzed intramolecular aryl amination followed by allylic amination pathway. The reaction between a series of MBH alcohols and amino compounds (Tosyl, aliphatic and aromatic amines) under optimized reaction conditions with Pd(PPh3)(2)Cl-2/DPPP catalyst system, afforded the corresponding 1,2-dihydroquinolines upto 95 % isolated yield.

引用

页码：13598 / 13602

页数：5

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