Consequences of dextropropoxyphene market withdrawal in elderly patients with chronic pain

被引：14

作者：

Becquemont, Laurent ^{[1
,16
]}

Delespierre, Tiba ^{[1
]}

Bauduceau, Bernard ^{[2
]}

Benattar-Zibi, Linda ^{[3
]}

Berrut, Gilles ^{[4
]}

Corruble, Emmanuelle ^{[5
]}

Danchin, Nicolas ^{[6
]}

Derumeaux, Genevieve ^{[7
]}

Doucet, Jean ^{[8
]}

Falissard, Bruno ^{[9
]}

Forette, Francoise ^{[10
]}

Hanon, Olivier ^{[11
]}

Pasquier, Florence ^{[12
]}

Pinget, Michel ^{[13
,14
]}

Ourabah, Rissane ^{[15
]}

Bucher, Sophie ^{[15
]}

Lazkani, Aida ^{[1
]}

Piedvache, Celine ^{[1
]}

Bertin, Philippe ^{[16
]}

机构：

[1] Univ Paris Sud, Hop Bicetre, AP HP, Pharmacol Dept,Fac Med Paris Sud, F-94275 Le Kremlin Bicetre, France

[2] Hop Begin, Dept Endocrinol, St Mande, France

[3] ORPEA CLINEA, Puteaux La Defense, France

[4] Univ Hosp Ctr, Nantes, France

[5] Univ Paris Sud, Bicetre Univ Hosp, AP HP, Fac Med Paris Sud,Dept Psychiat,INSERM,U669, F-94275 Le Kremlin Bicetre, France

[6] HEGP, Paris, France

[7] Hosp Civils Lyon, Louis Pradel Hosp, Bron, France

[8] Univ Rouen, St Julien Univ Hosp, Rouen, France

[9] Univ Paris Sud, Hop Paul Brousse, AP HP, Fac Med Paris Sud,INSERM,U669,Biostat Dept, F-94275 Le Kremlin Bicetre, France

[10] Univ Paris 05, Natl Fdn Gerontol, Paris, France

[11] Univ Paris 05, Hop Broca, AP HP, EA 4468,Geriatr Dept, Paris, France

[12] Univ Lille Nord France, Univ Hosp Ctr, UDSL, EA 1046, Lille, France

[13] Univ Strasbourg, Endocrinol Diabet & Dis Nutr Pole NUDE, Univ Hosp Strasbourg, Strasbourg, France

[14] Univ Strasbourg, European Ctr Study Diabet CeeD, Strasbourg, France

[15] Univ Paris Sud, Fac Med Paris Sud, Dept Gen Practice, F-94275 Le Kremlin Bicetre, France

[16] Hop Bicetre, Ctr Rech Clin, F-94275 Le Kremlin Bicetre, France

来源：

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY | 2014年 / 70卷 / 10期

关键词：

Dextropropoxyphene; Safety-based drug withdrawals; Chronic pain; Elderly patients; PATIENTS AGED 65; THERAPEUTIC MANAGEMENT;

D O I：

10.1007/s00228-014-1722-x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Describe the consequences of dextropropoxyphene (DXP) market withdrawal on analgesic prescriptions and on the quality of therapeutic management of chronic pain. From a cohort of non-institutionalised elderly patients with chronic pain recruited by general practitioners, we selected patients who were treated with DXP daily for at least 6 months just prior to DXP market withdrawal and who had an evaluation of pain and its impact on daily activities before and after DXP withdrawal. One hundred three patients took DXP daily for chronic pain. Immediately after DXP market withdrawal, 42 (40.8 %), 55 (53.4 %) and 3 (2.9 %) patients were treated with step 1, 2 and 3 analgesics, respectively, and 3 patients (2.9 %) were no longer receiving any analgesic medication. Among the 55 patients who continued on step 2 analgesics, 37 were treated with tramadol, 14 with codeine and 9 with opium. Pain intensity and the impact of pain on daily activities remained stable. DXP market withdrawal had no consequences on the intensity or impact of chronic pain in elderly patients.

引用

页码：1237 / 1242

页数：6

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