Caveolin-1 in oral squamous cell carcinoma microenvironment: an overview

被引：12
|
作者：
Routray, Samapika [1 ]
机构：
[1] SOA Univ, Inst Dent Sci, Dept Oral Pathol & Microbiol, Bhubaneswar 751003, Orissa, India
来源：
TUMOR BIOLOGY | 2014年 / 35卷 / 10期
关键词：
Cav-1; Oxidative stress; Hypoxia; Tumor microenvironment; OSCC; HNSCC; CANCER-ASSOCIATED FIBROBLASTS; NF-KAPPA-B; TUMOR MICROENVIRONMENT; BREAST-CANCER; OXIDATIVE STRESS; STROMAL CAVEOLIN-1; PROSTATE-CANCER; BETA-CATENIN; LIPID RAFTS; E-CADHERIN;
D O I：
10.1007/s13277-014-2482-z
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Caveolin-1 plays an important role in the pathogenesis of oncogenic cell transformation, tumorigenesis, and metastasis. Increased expression of caveolin-1 in an array of tumors has confirmed its value in prognosis. It has been established that oxidative stress is the main cause for loss of stromal caveolin-1 via autophagy in the tumor microenvironment. In this overview, we attempt to abridge the relationship between caveolin-1 and oral squamous cell carcinoma, taking all the established theories into consideration.
引用
收藏
页码：9487 / 9495
页数：9
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