Hemorrhagic stroke associated with essential thrombocythemia: Case report and literature review

被引：4

作者：

Momozaki, Akihiko ^{[1
]}

Masuoka, Jun ^{[1
]}

Furukawa, Takashi ^{[1
]}

Koguchi, Motofumi ^{[1
]}

Ito, Hiroshi ^{[1
]}

Yoshioka, Fumitaka ^{[1
]}

Inoue, Kohei ^{[1
]}

Ogata, Atsushi ^{[1
]}

Nakahara, Yukiko ^{[1
]}

Abe, Tatsuya ^{[1
]}

机构：

[1] Saga Univ, Fac Med, Dept Neurosurg, 5-1-1 Nabeshima, Saga 8498501, Japan

来源：

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES | 2020年 / 29卷 / 10期

关键词：

Essential thrombocythemia; Hemorrhagic stroke; Calreticulin; Vasoconstriction; Vasodilation; ISCHEMIC-STROKE;

D O I：

10.1016/j.jstrokecerebrovasdis.2020.105069

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Hemorrhagic stroke associated with essential thrombocythemia (ET) is very infrequent. Herein, we report a case of a 33-year-old woman with a 2-year history of ET who developed intracerebral and subarachnoid hemorrhage. Angiography demonstrated severe vessel irregularity in the bilateral cerebral arteries. Molecular genetic testing revealed a calreticulin mutation. To our knowledge, hemorrhagic stroke has been reported in only six other patients with ET, and this is the first report of hemorrhagic stroke in an ET patient with a calreticulin mutation. We review the current literature and discuss the possible underlying mechanisms. (c) 2020 Elsevier Inc. All rights reserved.

引用

页数：4

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