Immunological memory within the innate immune system

被引：90

作者：

Sun, Joseph C. ^{[1
,2
]}

Ugolini, Sophie ^{[3
,4
,5
]}

Vivier, Eric ^{[3
,4
,5
,6
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Program Immunol, New York, NY 10021 USA

[2] Weill Cornell Med Coll, Immunol & Microbial Pathogenesis Program, New York, NY USA

[3] UM2 Aix Marseille Univ, Ctr Immunol Marseille Luminy, Marseille, France

[4] INSERM, U1104, F-13258 Marseille, France

[5] CNRS, UMR7280, Marseille, France

[6] Hop Conception, AP HP, Serv Immunol, Marseille, France

来源：

EMBO JOURNAL | 2014年 / 33卷 / 12期

基金：

欧洲研究理事会;

关键词：

immunity; innate immunity; memory; NK cells; NATURAL-KILLER-CELLS; MOLONEY LEUKEMIA-CELLS; MOUSE LYMPHOID-CELLS; NKG2C(+) NK CELLS; C; ELEGANS; CYTOTOXIC REACTIVITY; ALLOGENEIC TUMORS; ADAPTIVE IMMUNITY; CANDIDA-ALBICANS; STEADY-STATE;

D O I：

10.1002/embj.201387651

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Immune memory has traditionally been the domain of the adaptive immune system, present only in antigen-specific T and B cells. The purpose of this review is to summarize the evidence for immunological memory in lower organisms (which are not thought to possess adaptive immunity) and within specific cell subsets of the innate immune system. A special focus will be given to recent findings in both mouse and humans for specificity and memory in natural killer (NK) cells, which have resided under the umbrella of innate immunity for decades. The surprising longevity and enhanced responses of previously primed NK cells will be discussed in the context of several immunization settings.

引用

页码：1295 / 1303

页数：9

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