Discovery of JNJ-787: An Hpk1 inhibitor that enhances the anti-tumor immunity of anti-PD1 in mice

被引：0

作者：

Mevellec, Laurence ^{[2
]}

Descamps, Sophie ^{[2
]}

Adelinet, Christophe ^{[2
]}

Wroblowski, Berthold ^{[1
]}

Vreys, Veronique ^{[1
]}

Valckx, Annemie ^{[1
]}

Boeckx, Inge ^{[1
]}

Van Slycken, Nele ^{[1
]}

Paulussen, Caroline ^{[1
]}

Leclercq, Laurent ^{[1
]}

Verhulst, Tinne ^{[1
]}

Van der Leede, Bas-jan ^{[1
]}

Angibaud, Patrick ^{[2
]}

Meerpoel, Lieven ^{[1
]}

Edwards, James ^{[3
]}

Laquerre, Sylvie ^{[3
]}

Lorenzi, Matt ^{[3
]}

Vialard, Jorge ^{[1
]}

机构：

[1] Janssen Res & Dev, Beerse, Belgium

[2] Janssen Res & Dev, Val De Reuil, France

[3] Janssen Res & Dev, Spring House, PA USA

来源：

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY | 2019年 / 257卷

关键词：

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

引用

页数：1

共 50 条

[31] HPK1 inhibitor reinvigorates exhausted tumor-infiltrating CD8 T cells and synergizes with anti-PD-1 blockade in gynecologic malignancies
Park, Junsik
Lee, Yong Jae
Kim, Sunghoon
Lim, Seungmook
Park, A. Yeong
Kim, Jamie Jae Eun
Lee, Jinhwa
Kim, Sang Wun
Park, Su-Hyung
Lee, Jung-Yun
CANCER RESEARCH, 2024, 84 (06)
[32] PD-1 BLOCKADE ADMINISTERED BEFORE OR AT THE TIME OF T CELL ACTIVATION ENHANCES ANTI-TUMOR IMMUNITY
Moseman, Jena
McNeel, Douglas
JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2022, 10 : A492 - A492
[33] Targeting glycosylated PD-1 induces potent anti-tumor immunity
Wang, Yuhan
Sun, Linlin
Yang, Riyao
Liu, Jielin
Qiu, Yufan
Hsu, Jennifer L.
Cha, Jong-ho
Chan, Li-Chuan
Hsu, Jung-Mao
Lee, Heng-Huan
Lai, Yun-Ju
Khoo, Kay-Hooi
Chung, Ezra M.
Li, Chia-Wei
Kim, Yong-Soo
Park, Andrew H.
Yang, Yi
Yoo, Stephen S.
Hung, Mien-Chie
CANCER RESEARCH, 2020, 80 (16)
[34] The combination of oxaliplatin and anti-PD-1 inhibitor promotes immune cells infiltration and enhances anti-tumor effect of PD-1 blockade in bladder cancer
Zhao, Zihan
Liu, Siyang
Sun, Rui
Zhu, Wenjie
Zhang, Yulin
Liu, Tianyao
Li, Tianhang
Jiang, Ning
Guo, Hongqian
Yang, Rong
FRONTIERS IN IMMUNOLOGY, 2023, 14
[35] Methyltransferase-like 3 (METTL3) inhibition potentiates anti-tumor immunity: a novel strategy for improving anti-PD1 therapy
Anna Brichkina
Roman Suezov
Magdalena Huber
Signal Transduction and Targeted Therapy, 8
[36] Methyltransferase-like 3 (METTL3) inhibition potentiates anti-tumor immunity: a novel strategy for improving anti-PD1 therapy
Brichkina, Anna
Suezov, Roman
Huber, Magdalena
SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2023, 8 (01)
[37] Fucoidan enhances the anti-tumor effect of anti-PD-1 immunotherapy by regulating gut microbiota
Li, Hui
Dong, Tieying
Tao, Meng
Zhao, Haifeng
Lan, Tongtong
Yan, Shiyu
Gong, Xinyi
Hou, Qilong
Ma, Xuezhen
Song, Yang
FOOD & FUNCTION, 2024, 15 (07) : 3463 - 3478
[38] Fungal Depletion Bolsters Anti-Tumor Immune Response Elicited by Anti-PD1 Alone and in Combination with Radiation Therapy
Stevens, S.
Jang, J. K.
Kershaw, K.
Viramontes, J.
Dar, T. B.
Nguyen, A. T.
Henson, R.
Guarnerio, J.
Underhill, D.
Shiao, S. L.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2023, 117 (02): : S166 - S166
[39] Combination of a novel HDAC6 inhibitor ACY-241 and anti-PD-L1 antibody enhances anti-tumor immunity and cytotoxicity in multiple myeloma
Ray, A.
Das, D. S.
Song, Y.
Hideshima, T.
Tai, Y-T
Chauhan, D.
Anderson, K. C.
LEUKEMIA, 2018, 32 (03) : 843 - 846
[40] Combination of a novel HDAC6 inhibitor ACY-241 and anti-PD-L1 antibody enhances anti-tumor immunity and cytotoxicity in multiple myeloma
A Ray
D S Das
Y Song
T Hideshima
Y-T Tai
D Chauhan
K C Anderson
Leukemia, 2018, 32 : 843 - 846

← 1 2 3 4 5 →