Disease mechanism - Unravelling Wiskott-Aldrich syndrome

被引：44
|
作者：
Kirchhausen, T [1 ]
Rosen, FS [1 ]
机构：
[1] HARVARD UNIV,SCH MED,CTR BLOOD RES,BOSTON,MA 02115
来源：
CURRENT BIOLOGY | 1996年 / 6卷 / 06期
关键词：
D O I：
10.1016/S0960-9822(09)00447-3
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The gene responsible for Wiskott-Aldrich syndrome, a disease affecting platelets and lymphocytes, has been cloned and its protein product (WASp) found to interact with the GTPase Cdc42. WASp seems to provide a link between Cdc42 and the actin cytoskeleton, perhaps explaining the cellular defects underlying the disease.
引用
收藏
页码：676 / 678
页数：3
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