A mild synthetic procedure for the preparation of N-alkylated sulfoximines

被引：0

作者：

Bolm, C ^{[1
]}

Hackenberger, CPR ^{[1
]}

Simic, O ^{[1
]}

Verrucci, M ^{[1
]}

Müller, D ^{[1
]}

Bienewald, F ^{[1
]}

机构：

[1] Rhein Westfal TH Aachen, Inst Organ Chem, D-52056 Aachen, Germany

来源：

SYNTHESIS-STUTTGART | 2002年 / 07期

关键词：

acylation; borane; chirality; reduction; sulfoximine;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

N-Alkylated sulfoximines have been synthesized in good yields by acylation of NH-sulfoximines followed by carbonyl reduction with complexed boranes. Enantiopure substrates react without racemization, and stereogenic centers originating from the acylating component are retained. If the acylation is performed by DCC coupling, this two-step procedure represents a rare example of a formal N-alkylation of sulfoximines under base-free conditions.

引用

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页码：879 / 887

页数：9

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