High-rise buildings, as a result of rapid urbanization in China, become one of popular structure kind. However, been few seismic vulnerability studies on high-rise, buildings have been done, and few fragility curves were developed for the buildings. Our study is based on the published data from more than 50 high rises and super high rises. The structural information such as building heights, mode periods, locations and sites, and the maximum design story drift ratios, are collected and analyzed. By considering the structural primary periods, buildings are categories into different height groups. Geological conditions of the building site such as soil types, site characteristic periods, are also considered. The vulnerability analysis for high rises uses response spectrum displacement as seismic ground motion input, since the structures have comparatively long natural period. Statistics and regression analysis of linear least square method are used. The relationship between the maximum story drift ratio and response spectrum displacement is established. With cumulative normal distribution, and based on height groups and earthquake design codes, the fragility curves of different performance levels have been developed. These curves provide good estimation of high rise structural damage under earthquake ground motion.