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- [24] A multicenter, randomized, double-blind, placebo-controlled, 8-week trial of the efficacy and tolerability of once-daily Losartan 100 mg/hydrochlorothiazide 25 mg and Losartan 50 mg/hydrochlorothiazide 12.5 mg in the treatment of moderate-to-severe essential hypertension CLINICAL THERAPEUTICS, 2002, 24 (07) : 1049 - 1061