A simple and efficient new approach to the total synthesis of (+/-)-4-amino-3-(4-chlorophenyl)-butyric acid (BACLOFEN)

被引：14
|
作者：
Coelho, F
deAzevedo, MBM
Boschiero, R
Resende, P
机构：
[1] UNICAMP, Instituto de Química, Depto. de Quim. Orgânica, 13083-970 - Campinas, SP
来源：
SYNTHETIC COMMUNICATIONS | 1997年 / 27卷 / 14期
基金：
巴西圣保罗研究基金会;
关键词：
D O I：
10.1080/00397919708004109
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Based on the utilization of a [2+2] cycloaddition reaction between dichloroketene and an appropriated olefin as a key step, we describe a new and simple four step approach to the total synthesis of (+/-)-4-amino-3-(4-chlorophenyl)-butyric acid (BACLOFEN), a selective GABA(B) agonist used as antispastic agent.
引用
收藏
页码：2455 / 2465
页数：11
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