Frequencies of the DRB1, DQA1, DQB1 and TNFA alleles in immigrant population of west Siberia

被引：1
|
作者：
Golovanova, O. V. [1 ]
Konenkov, V. I. [1 ]
Shevchenko, A. V. [1 ]
Smolnikova, M. V. [2 ]
机构：
[1] Russian Acad Med Sci, Res Inst Clin & Expt Lymphol, Novosibirsk 630117, Russia
[2] Res Inst Med Problems, Krasnoyarsk 660022, Russia
来源：
RUSSIAN JOURNAL OF GENETICS | 2009年 / 45卷 / 08期
关键词：
HLA CLASS-II; FACTOR-ALPHA PROMOTER; POLYMORPHISM; HAPLOTYPES; DATABASES; HLA-DR3; REGION;
D O I：
10.1134/S1022795409080134
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Based on population analysis of the DRB1, DQA1, DQB1 and TNFA allele frequency distribution patterns, regional features of immunogenetic structure of the population of West Siberia were investigated. Statistically significant linkage disequilibrium within the HLA class II region, as well as between the TNFA and DRB1, DQA1, and DQB1 was demonstrated. Population frequency distribution patterns of two- and multilocus haplotypes were examined.
引用
收藏
页码：981 / 986
页数：6
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