The difference in histological yield between 19G EUS-FNA and EUS-fine-needle biopsy needles

Background and Objective: EUS-guided fine-needle biopsy (EUS-FNB) with acquisition of tissue core is possible with the use of 19G fine-needle aspiration (FNA) and dedicated biopsy needles. Published data of direct comparisons between biopsy needles are more limited compared to the abundant data comparing EUS-FNA with EUS-FNB. We performed a retrospective study - to determine the difference in histologic 3, field between 19G FNA needle and EUS-FNB needles in patients with solid masses. Materials and Methods: Consecutive patients who underwent EUS-FNB of solid masses from January 2014 to July 2018 were identified from a database. The difference in histologic), yield between needles w as analyzed. Results: A total of 159 patients underwent 179 EU S-FNB procedures (median of 2 needle passes 'range: 1-41). The use of 19G FNA, 19G, 20G. and 22G FNB needles allowed acquisition of a histologic core in 67.4% (29/43). 72.5% (29/40). 82.1% (46/56). and 75.9% (22/29), respectively (P = 0.368). A significant difference in the 3, yield of histologic core was detected when 19G FNA needle was compared with 22G Acquire (TM) FNB needle (67.4%[29/43] vs 94.1% [16/17], P = 0.032). The presence of histologic core was significantly - associated with a positive diagnosis (95.6% vs. 30.2%. P < 0.0001). Conclusion: EU S-FNB with acquisition of histologic core improved the diagnostic), yield. Dedicated FNB needles appeared to achieve a higher yield of histologic core compared to 19G FNA needles.