Wogonin inhibits IL-6-induced angiogenesis via down-regulation of VEGF and VEGFR-1, not VEGFR-2

被引：30

作者：

Lin, Chiu-Mei

Chang, Hang

Chen, Yeh-Hsu

Wu, I-Hsing

Chiu, Jen-Hwey

机构：

[1] Natl Yang Ming Univ, Sch Med, Inst Tradit Med, Taipei 112, Taiwan

[2] Shin Kong Wu Ho Su Mem Hosp, Dept Emergency Med, Taipei, Taiwan

[3] Taipei City Hosp, Taipei, Taiwan

[4] Taipei Med Univ, Coll Med, Taipei, Taiwan

[5] Vet Gen Hosp, Dept Surg, Div Gen Surg, Taipei, Taiwan

[6] Kaohsiung Med Univ, Chung Ho Mem Hosp, Dept Internal Med, Div Infect Dis, Kaohsiung, Taiwan

[7] Vet Gen Hosp, Res Ctr Tradit Chinese Med, Taipei, Taiwan

来源：

PLANTA MEDICA | 2006年 / 72卷 / 14期

关键词：

wogonin; angiogenesis; IL-6; IL-6R; VEGF; VEGFR-1;

D O I：

10.1055/s-2006-951692

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

So far, no antiangiogenic activity of wogonin, a flavonoid, on human umbilical vein enclothelial cells (HUVECs) has been demonstrated. The aim of this study was to investigate the effects of wogonin on IL-6-induced angiogenesis in HUVEC cultures and chorioallantoic membrane (CAM) neovascularization. The in vivo CAM model was applied to evaluate the percentage of new vessel formations, followed by measurement of endothelial migration and tube formation in HUVEC cultures. The results revealed that wogonin (10-8-10-5M) concentration-dependently

引用

页码：1305 / 1310

页数：6

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