Wogonin inhibits IL-6-induced angiogenesis via down-regulation of VEGF and VEGFR-1, not VEGFR-2

被引：30
|
作者：
Lin, Chiu-Mei
Chang, Hang
Chen, Yeh-Hsu
Wu, I-Hsing
Chiu, Jen-Hwey
机构：
[1] Natl Yang Ming Univ, Sch Med, Inst Tradit Med, Taipei 112, Taiwan
[2] Shin Kong Wu Ho Su Mem Hosp, Dept Emergency Med, Taipei, Taiwan
[3] Taipei City Hosp, Taipei, Taiwan
[4] Taipei Med Univ, Coll Med, Taipei, Taiwan
[5] Vet Gen Hosp, Dept Surg, Div Gen Surg, Taipei, Taiwan
[6] Kaohsiung Med Univ, Chung Ho Mem Hosp, Dept Internal Med, Div Infect Dis, Kaohsiung, Taiwan
[7] Vet Gen Hosp, Res Ctr Tradit Chinese Med, Taipei, Taiwan
来源：
PLANTA MEDICA | 2006年 / 72卷 / 14期
关键词：
wogonin; angiogenesis; IL-6; IL-6R; VEGF; VEGFR-1;
D O I：
10.1055/s-2006-951692
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
So far, no antiangiogenic activity of wogonin, a flavonoid, on human umbilical vein enclothelial cells (HUVECs) has been demonstrated. The aim of this study was to investigate the effects of wogonin on IL-6-induced angiogenesis in HUVEC cultures and chorioallantoic membrane (CAM) neovascularization. The in vivo CAM model was applied to evaluate the percentage of new vessel formations, followed by measurement of endothelial migration and tube formation in HUVEC cultures. The results revealed that wogonin (10-8-10-5M) concentration-dependently
引用
收藏
页码：1305 / 1310
页数：6
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