The sequence-structure relationship and protein function prediction

被引：72
|
作者：
Sadowski, M. I. [2 ]
Jones, D. T. [1 ]
机构：
[1] UCL, Dept Comp Sci, London WC1E 6BT, England
[2] Natl Inst Med Res, Div Math Biol, London NW7 1AA, England
来源：
CURRENT OPINION IN STRUCTURAL BIOLOGY | 2009年 / 19卷 / 03期
关键词：
GENE ONTOLOGY ANNOTATIONS; CONVERGENT EVOLUTION; PARACELSUS CHALLENGE; DOMAIN-STRUCTURES; LIGAND-BINDING; SITES; IDENTITY; DESIGN; FOLDS; CLASSIFICATION;
D O I：
10.1016/j.sbi.2009.03.008
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
An incomplete understanding of protein sequence/structure/function relationships causes man difficulties for prediction methods. The highly complex nature of these relationships is a consequence of the interplay between physics and evolution that has been studied using a wide array of experimental and theoretical techniques. We review recent findings relating to conservation of sequence, structure and function and discuss their use in developing improved prediction methods.
引用
收藏
页码：357 / 362
页数：6
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