A predictive survival model for patients with head and neck squamous cell carcinoma treated with immune check point inhibitors

被引：6
|
作者：
Bonomi, M. [1 ]
Bhateja, P. [1 ]
Issa, M. [1 ]
Klamer, B. [2 ]
Pan, X. [2 ]
Blakaj, A. [3 ]
Karivedu, V [1 ]
Mousa, L. [1 ]
Mitchell, D. [5 ]
Gamez, M. [5 ]
Kang, S. [4 ]
Seim, Nolan B. [4 ]
Old, M. [4 ]
Carrau, R. [4 ]
Rocco, J. [4 ]
Blakaj, D. [5 ]
机构：
[1] Ohio State Univ, Div Med Oncol, Columbus, OH 43210 USA
[2] Ohio State Univ, Dept Biomed Informat, Columbus, OH 43210 USA
[3] Yale Univ, Div Radiat Oncol, New Haven, CT USA
[4] Ohio State Univ, Div Otolaryngol, Columbus, OH 43210 USA
[5] Ohio State Univ, Div Radiat Oncol, Columbus, OH 43210 USA
来源：
ORAL ONCOLOGY | 2020年 / 110卷
关键词：
PD-1; inhibitors; Metastatic; Head and neck cancer; Response; Predictors; Immunotherapy; CANCER; IMMUNOTHERAPY; NIVOLUMAB; RECURRENT; INDEX;
D O I：
10.1016/j.oraloncology.2020.104900
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Background: ICIs have expanded treatment options for HNSCC. A minority of the patients respond to these expensive treatments. Patients and methods: This is a single institutional retrospective review on 121 unresectable or metastatic HNSCC patients treated with ICIs. We predicted that inflammatory markers available through routine blood work, in addition to clinical characteristics may divide patients into groups more or less likely to respond to these agents. Here we develop and internally validate our nomogram to predict survival in patients treated with ICIs.
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页数：6
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