Anionic inverse electron-demand 1,3-dipolar cycloaddition of nitrones with ynolates.: Facile stereoselective synthesis of 5-isoxazolidinones leading to β-amino acids

被引：33

作者：

Shindo, M ^{[1
]}

Itoh, K ^{[1
]}

Tsuchiya, C ^{[1
]}

Shishido, K ^{[1
]}

机构：

[1] Univ Tokushima, Inst Med Resources, Tokushima 7708505, Japan

来源：

ORGANIC LETTERS | 2002年 / 4卷 / 18期

关键词：

D O I：

10.1021/ol0264455

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] The inverse electron-demand 1,3-dipolar cycloaddition of nitrones with ynolates, followed by quenching with t-BuOH, produced substituted 5-isoxazolidinones with good trans-selectivity. These products were easily converted into beta-amino acids.

引用

页码：3119 / 3121

页数：3

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