Prostaglandin F2α increases the sensitivity of the contractile proteins to Ca2+ in human myometrium

被引：19
|
作者：
Woodcock, Nicola A. [1 ]
Taylor, Colin W.
Thornton, Steven
机构：
[1] Univ Warwick, Dept Biol Sci, Coventry CV4 7AL, W Midlands, England
[2] Univ Cambridge, Dept Pharmacol, Cambridge CB2 1QJ, England
[3] Univ Warwick, Sch Med, Coventry CV4 7AL, W Midlands, England
[4] Univ Hosp Coventry & Warwickshire, Coventry, W Midlands, England
来源：
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY | 2006年 / 195卷 / 05期
关键词：
myometrial contraction; PGF(2 alpha); Ca2+-sensitivity;
D O I：
10.1016/j.ajog.2006.03.099
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
It is not known whether agonists (other than oxytocin) increase the contractile protein sensitivity to intracellular calcium ([Ca2+](i)) in human myometrium. We determined the calcium-tension relationship in the presence and absence of prostaglandin F-2 alpha (PGF(2 alpha)). PGF(2 alpha) increased the calcium sensitivity during both the contractile (rising) and relaxation (falling) phases of a contraction. (c) 2006 Mosby, Inc. All rights reserved.
引用
收藏
页码：1404 / 1406
页数：3
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