Drawing on nearly 45 years as a communicator and leader in the chemical sciences, I describe herewith my life's journey, from a young girl growing up in my grandmother's house in Washington, D.C., to becoming the chief executive officer of the world's largest scientific society. At each transition in my personal and professional career, I realized that I had learned a lesson, even if I had not realized it at the time. Students to seasoned professionals should be prepared to nod with recognition, laugh, and even cry, from my first lesson, "Never do anything just to please your mother," to Lesson Number 10, "Experiment!" This article will provide insights on how to build a satisfying career and personal life.