Direct synthesis of polysubstituted 2-aminothiophenes by Cu(II)-catalyzed addition/oxidative cyclization of alkynoates with thioamides

被引：27
|
作者：
Ge, Li-Shi [1 ]
Wang, Zheng-Lin [1 ]
An, Xing-Lan [1 ]
Luo, Xiaoyan [1 ]
Deng, Wei-Ping [1 ]
机构：
[1] E China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Funct Mat Chem, Shanghai 200237, Peoples R China
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2014年 / 12卷 / 42期
关键词：
ONE-POT SYNTHESIS; HIGHLY SUBSTITUTED THIOPHENES; CATALYZED AMINATION; EFFICIENT SYNTHESIS; COPPER(I)-CATALYZED SYNTHESIS; PHARMACOLOGICAL EVALUATION; 1,3-DICARBONYL COMPOUNDS; ANTIINFLAMMATORY AGENTS; BETA-KETOTHIOAMIDES; S-ALKENYLATION;
D O I：
10.1039/c4ob01534g
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A facile and direct synthetic method was developed for the construction of structurally important 2-aminothiophenes in moderate to excellent yields (up to 91%), via Cu(II)-catalyzed addition/oxidative cyclization of readily available thioamides with alkynoates under an air atmosphere.
引用
收藏
页码：8473 / 8479
页数：7
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