SILENCING THE INHIBITORY CHECKPOINT CD96 ENHANCES THE CYTOTOXIC POTENTIAL OF NATURAL KILLER CELLS AGAINST MULTIPLE MYELOMA

被引:0
|
作者
Duggan, T. [1 ]
Chauhan, S. [1 ,2 ]
Daly, J. [1 ]
Sarkar, S. [1 ,2 ]
O'Dwyer, M. [1 ,2 ]
机构
[1] Natl Univ Ireland Galway, Biomed Sci, Apoptosis Res Ctr, Galway, Ireland
[2] Onkimmune Ltd, Galway, Ireland
关键词
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
P06
引用
收藏
页码:16 / 16
页数:1
相关论文
共 50 条
  • [21] Feeder-free differentiation of human iPSCs into natural killer cells with cytotoxic potential against malignant brain rhabdoid tumor cells
    Kiran, Sonia
    Xue, Yu
    Sarker, Drishty B.
    Li, Yan
    Sang, Qing-Xiang Amy
    BIOACTIVE MATERIALS, 2024, 36 : 301 - 316
  • [22] Killing activity of inhibitory natural killer cell receptor CD94-expressing CD8 T cells against primary leukemic cells
    Tanaka, J
    Toubai, T
    Miura, Y
    Kato, N
    Shigematsu, A
    Iwao, N
    Ota, S
    Asaka, M
    Imamura, M
    EXPERIMENTAL HEMATOLOGY, 2004, 32 (07) : 49 - 50
  • [23] Restoration of NK cell function against multiple myeloma cells by an adjunctive effect of activated invariant natural killer T (NKT) cells
    Iyoda, Tomonori
    Yamasaki, Satoru
    Hidaka, Michihiro
    Kawano, Fumio
    Abe, Yu
    Suzuki, Kenshi
    Kadowaki, Norimitsu
    Shimizu, Kanako
    Fujii, Shin-ichiro
    CYTOKINE, 2017, 100 : 128 - 129
  • [24] Cytotoxic activity of natural killer cells lacking killer-inhibitory receptors for self-HLA class I molecules against autologous hernatopoietic stem cells in healthy individuals
    Grau, R
    Lang, KS
    Wernet, D
    Lang, P
    Niethammer, D
    Pusch, CM
    Handgretinger, R
    EXPERIMENTAL AND MOLECULAR PATHOLOGY, 2004, 76 (02) : 90 - 98
  • [25] Novel Monoclonal Antibody Enhances Natural Killer (NK) Cell Cytotoxicity against Multiple Myeloma (MM): Interim Phase 1 Trial Results
    Benson, Don
    Hofmeister, Craig C.
    Padmanabhan, Swaminathan
    Abonour, Rafat
    Suvannasankha, Attaya
    Mita, Alain
    Squiban, Patrick
    Smith, Megan K.
    Bakan, Courtney E.
    Marzetto, Marc
    Andre, Pascale
    Tollier, Jerome
    Caligiuri, Michael A.
    Farag, Sherif
    BLOOD, 2009, 114 (22) : 1125 - 1125
  • [26] CT-011, a monoclonal PD-1 blocking antibody, enhances natural killer cell activation and cytotoxicity against multiple myeloma
    Benson, Don
    Chandler, Jason
    Mishra, Anjali
    Baiocchi, Robert
    Yu, Jianhua
    Liu, Tom
    Lozanski, Gerard
    Porcu, Pierluigi
    Devine, Steven
    Rotem-Yehudar, Rinat
    Caligiuri, Michael
    CANCER RESEARCH, 2009, 69
  • [27] Targeting PD1–PDL1 immune checkpoint in plasmacytoid dendritic cell interactions with T cells, natural killer cells and multiple myeloma cells
    A Ray
    D S Das
    Y Song
    P Richardson
    N C Munshi
    D Chauhan
    K C Anderson
    Leukemia, 2015, 29 : 1441 - 1444
  • [28] Natural killer cells and CD56(+) T cells in the flood of multiple myeloma patients: Analysis by 4-colour flow cytometry
    King, MA
    RadicchiMastroianni, MA
    CYTOMETRY, 1996, 26 (02): : 121 - 124
  • [29] RNA Polymerase I Inhibition and activation of Nucleolar Stress Response in the anticancer activity of Natural Killer cells against Multiple Myeloma
    Sproviero, Elena
    Cipollone, Tommaso
    Gnocchini, Eleonora
    Petillo, Sara
    Cassone, Chiara
    Zingoni, Alessandra
    Soriani, Alessandra
    Cerboni, Cristina
    Petrucci, Maria Teresa
    Fazio, Francesca
    Cippitelli, Marco
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2024, 54 : 1077 - 1077
  • [30] CD28 expression on multiple myeloma cells enhances the cytotoxic activity of CD38/CD28xCD3 trispecific T cell engager
    El-Murr, Nizar
    Henry, Christophe
    Francesconi, Elisa
    Attenot, Florence
    Virone-Oddos, Angela
    Vidard, Laurent
    Wu, Lan
    Yang, Zhi-Yong
    Chiron, Marielle
    CANCER RESEARCH, 2020, 80 (16)