Aromatic Ring Substituted Aaptamine Analogues as Potential Cytotoxic Agents against Extranodal Natural Killer/T-Cell Lymphoma

被引：7
|
作者：
Yang, Fan [1 ]
Gao, Yuan [1 ]
Chang, Yung-Ting [1 ]
Zou, Yike [2 ]
Houk, K. N. [2 ]
Lu, Jing-Rong [1 ]
He, Jing [1 ]
Tang, Wei-Zhuo [3 ]
Liao, Hong-Ze [1 ]
Han, Hua [4 ]
Lin, Hou-Wen [1 ]
机构：
[1] Shanghai Jiao Tong Univ, Renji Hosp, Res Ctr Marine Drugs,Dept Pharm, Sch Med,State Key Lab Oncogenes & Related Genes, Shanghai 200127, Peoples R China
[2] Univ Calif Los Angeles, Dept Chem & Biochem, Los Angeles, CA 90095 USA
[3] Changsha Univ, Coll Biol & Environm Engn, Changsha 410022, Peoples R China
[4] Tongji Univ, Sch Med, Shanghai 200092, Peoples R China
来源：
JOURNAL OF NATURAL PRODUCTS | 2020年 / 83卷 / 12期
基金：
中国国家自然科学基金;
关键词：
ANTINEOPLASTIC AGENTS; ISOAAPTAMINE; DERIVATIVES; PROGRESSION; PRODUCT;
D O I：
10.1021/acs.jnatprod.0c00769
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
A chemical modification study was conducted on the marine natural product aaptamine (1), isolated from the marine sponge Aaptos aaptos. Thirty new derivatives substituted by various aromatic rings at the 3- and 7-positions of aaptamine were prepared by bromination, followed by the Suzuki coupling reaction. Sixteen compounds displayed cytotoxicities to four cancer cell lines (IC50 < 10 mu M). In particular, compound 5i demonstrated a significant antiproliferative effect on the extranodal natural killer/T-cell lymphoma (ENKT) cell line SNK-6 with an IC50 value of 0.6 mu M. Additionally, compound 5i showed cytotoxicities to multiple lymphoma cell lines, including Ramos, Raji, WSU-DLCL2, and SU-DHL-4 cells.
引用
收藏
页码：3758 / 3763
页数：6
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